Dr. Anshika Srivastava is an Assistant Professor at the Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, U.P., INDIA. She received her postgraduate degree from the department of biochemistry, University of Lucknow (2005-2007), and completed her Ph.D. at SGPGIMS, Lucknow (2008-2013). After defending her Ph.D., she moved to University of Michigan, Ann Arbor, Michigan, USA, for her postdoctoral training in the department of human genetics, where she performed research at the interface of patient care and basic science. Dr. Srivastava’s studies of neurologic and cardiac Mendelian diseases have advanced current understanding of: i) gene dosage in trait manifestation, ii) disease allele pathogenicity, iii) the importance of alleles combination in susceptibility to complex traits iv) and role of the dynamic balance of histone H2A mono-ubiquitination in early development and disease. Dr. Srivastava also developed a new mouse genotyping strategy that circumvents deficiencies of traditional genotyping strategy that do not differentiate between CRISPR/Cas9 edited alleles. To date, she has co-authored 30 scientific research articles and two book chapters. Research in Dr. Srivastava lab focuses on understanding the epigenetic and molecular mechanisms of stem cell multipotency, self-renewal, and cell-specific differentiation required building a functional heart and brain. The lab develops these projects from human genetic studies aimed at identifying the genetic basis of developmental disorders. A major challenge to investigating cell and molecular mechanisms of developmental disorders has been the lack of affected tissue. To address this problem Srivastava lab uses human brain organoid and cardiomyocyte cultures, differentiated from human pluripotent stem cells (hPSCs). Thus, the goal is to elucidate the pathology of clinically important disorders that have a component of affected brain and heart to delineate the novel features of human brain and heart development.