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Research Interest:Environmental chemical mediated renal toxicity, Uro-oncology, nephrolithiasis, Diabetic complications, Animal modeling for urological diseases
My research work is focused in the area of urological diseases (renal cell carcinoma, kidney stone, and prostate cancer), environmental chemical mediated renal toxicity, diabetes-mediated renal diseases, etc. we are using molecular biology, molecular genetics, cell biology, and biochemical approaches to reveal the biological mysteries. We use the genetically tractable alternate animal model Drosophila for modeling various human diseases. Currently, we are involved in deciphering the molecular basis of chemical-mediated kidney failure, diabetic nephropathy, and kidney stone. We are also involved in the identification of prognostic as well as diagnostic biomarkers and therapeutics molecules for clear cell renal cell carcinoma and prostate cancer.
6. Research support/Projects :
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SN
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Title/ role
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Funding agency
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Duration and date of start
|
|
1.
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Deciphering molecular mechanisms and association of genetic variants of diabetic nephropathy. (PI)
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DST, New Delhi
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6 Years;
Nov 2015
|
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2.
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Study the toxic effects of exposure to Bisphenol A and Dibutyl phthalates on renal organ and identification of potential therapeutics for its mitigation by using Drosophila melanogaster model organism. (PI)
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DST, New Delhi
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3 Years;
March 2021
|
|
3.
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Development of non-invasive biomarker for early diagnosis of clear cell renal cell carcinoma (ccRCC) and identification of therapeutic target for the disease. (PI)
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SGPGIMS, Lucknow
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2 Years;
January 2021
|
|
4
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PDE-5 inhibitor Tadalafil as anti-inflammatory and antifibrotic agent for improving bladder dynamics in cases of posterior urethral valve. (Co-PI)
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SGPGIMS, Lucknow
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2 Years;
January 2021
|
|
5
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Detecting long non-coding RNA biomarkers in prostate cancer liquid biopsies. (Co-PI)
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SGPGIMS, Lucknow
|
2 Years;
January 2021
|
|
6
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Investigation of pathogenic genetic variants in COL4A3, GABRR1, ABCG8, AGER, IL10 and MMP9 genes in susceptibility to diabetic nephropathy in north Indian population. (PI)
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ICMR, New Delhi
(ICMR SRF)
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3 Years;
May 2022
|
|
7
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Study the molecular mechanism of nephrolithiasis
And screening of potential therapeutics for disease using Drosophila model. (PI)
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UPCST, Lucknow
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3 Years
September 2022
|
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8
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Investigating the mechanism/s of ochratoxin A-induced exosomes mediated renal toxicity. (Co-PI)
(In collaboration with CSIR-IITR, Lucknow).
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Core grant, SERB, New Delhi
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3 Years
March 2023
|
|
9.
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To investigate the association of GWAS identified high risk variants with diabetic nephropathy in North Indian population. (PI)
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SGPGIMS, Lucknow
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2 Year
March 2023
|
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10.
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To assess the role of Next Generation Sequencing in detecting genomic alteration advanced prostate cancer in Indian senario
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SGPGIMS, Lucknow
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2 Year
March 2023
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8. Teaching and Mentoring activities (in SGPGIMS) :
Teaching:I am actively involved in teaching Master (M.Sc and Ph.D. students. I am taking classes for master students of medical biotechnology and have also given my name as teaching faculty in Dept. of Molecular Medicine for upcoming master courses in the department. Apart from this, I have designed 1 credit course “Model system for Biomedical Research” for the coursework of Ph.D,/MD/MCh students.
Currently 3 Ph.D. students are working under my supervision in different research area (Renal cell carcinoma, renal toxicity, prostate cancer, diabetic nephropathy). Recently, a student for the post of research assistant has been recruited to work on nephrolithiasis. However, one position of JRF/PA has been advertised for the recruitment of the candidate.
List of students working under my supervision :
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SN
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Name
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Designation
|
Enrollment in Ph.D
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My role
|
|
1.
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NehaShukla
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Senior research fellow
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Perusing Ph.D.
|
Guide
|
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2.
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ShivaniKumari
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Junior Research fellow
|
Perusing Ph.D.
|
Guide
|
|
3.
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PoornimaVerma
|
Junior Research fellow
|
Perusing Ph.D.
|
Guide
|
|
4.
|
NaditaAnandVerma
|
Research Assistant
|
Not enrolled
|
Guide
|
|
5.
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Amisha
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Project Assistant
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Ph.D
|
Guide
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