Research Projects

Intramural

2020-2022
  • Validation of ‘Hi-Screen” test for COVID-19 Developed at SGPGI (From 15.12.2020 to 14.12.2022) (PI: Dr. Swasti Tiwari).
  • Targeting of Glioblastoma Stem Cells through modulation of mitochondrial mechanisms for developing effective Therapeutic Approaches (From 25.12.2020 to24.12.2022) (PI: Dr. Lokendra K. Sharma).
  • Comparison of Cytotrophoblast Cell-Fusion Markers in Placenta of Early and Term Gestation (A Pilot Study) (From 15.12.2020 to 14.12.2022) (PI: Dr. Santosh Kumar)
    • 2019-2021
  • Brain Ageing Research: Role of genetic modified extra cellular vesicles (EVs) in modulation of age related chronic neuroinflammation (From 01.09.2019 to 31.08.2021) (PI:Dr. Alok Kumar).
  • Development of predictive markers for maternal and neonatal health through investigation of mitochondrial changes during pregnancy (A pilot study) (From 01.09.2019 to 31.08.2021) (PI:Dr. Lokendra Kumar Sharma).
  • Gene expression analysis during trophoblast cell fusion process (From 01.09.2019 to 31.08.2021) (PI: Dr. Santosh Kumar)
    • 2018-2020
  • To examine the immunomodulatory effect of Umbilical cord blood Mesenchymal stem cells on HLA matched immune cell interactions in the context of Type 1 Diabetes (From 11.10.2018 to 10.10.2020) (PI: Dr. Swasti Tiwari)
    • 2015-2017
  • Analysis of Ghioconeogenic enzymes in Human urinary Exosomes : Pilot study (From 20 -10-2015 to 19-10-2017) (PI: Dr. Swasti Tiwari)
    • 2013-2015
  • Proteomic profiling of urinary exosomes from diabetic patients with microalbuminuria- Pilot study (From 26.03.2013 to 25.03.2015) (PI: Dr. Swasti Tiwari)
    • 2009-2011
    • To determine the usefulness of exasomes as a non-invasive marker for diabetic renal disease pilot –study (2009-2011) (PI: Dr. Swasti Tiwari)

    • Extramural

    • PI- Prof. Swasti Tiwari
    • ICMR(2023-2026): Renal transcriptome regulation in diabetic kidney disease.
    • DBT (2019-2022): Title: Monitoring placental health & function across pregnancy using nanovesicles-full.
    • ICMR (2019-2024): Centre for Advance Research and Excellence on Kidney disease: Biomarkers and Therapeutics
    • DST (Indo- Israel) (2018-2020): Exploring therapeutic potential of exosomes in Type I diabetes mellitus.
    • DST (2018-2021) , Role-Co-PI Umbilical cord mesenchymal stem cells derived exosomes as biogenic nanocarriers of miRNA and chemotherapeutic drug for reversal of chemoreistance in breast cancer.
    • DST-SERB (2018): International Symposium on Molecular Medicine 2018
    • UPCST (2017-2020) Effect of insulin signaling on tubular Albumin Reabsorption
    • ICMR ( 2017-2020)- Epigenetic modulation by statins in nephropathy
    • DST-SERB (2017-2020)- Role CO-PI: Medical Thermography and Gas Discharge Visualization technique: a diagnostic approach for type 2 diabetes based on non-contact infrared thermal imaging and Electro-photonic imaging: A multicentric study
    • DBT (2017-2019) Monitoring placental health & function across pregnancy using nanovesicles (pilot)
    • DBT (Completed in 2016) ‘Identifying renal repair and regeneration pathways using miRNA profiling’
    • DST (Completed in May 2015) Early diagnostic marker for diabetic nephropathy’
    • Department of Education, Ministry of HRD (2013-2021) Establishment of Centre of Excellence in Modern Biology
    • DBT (completed in August 2015) the causative role of reduced kidney-epithelial-cell insulin receptor in hypertension.
    • Dr. Alok Kumar
    • DHR (2022-2025): Role of human umbilical cord mesenchymal stromal cells (hucMSCs) derived exosomes in CNS drug delivery molecules for the modulation of chronic neuroinflammation, pain-related behavior and motor function in the young injured brain.
    • DBT (2022-2025): Determination and establishment of key molecular therapeutic approach for remodeling of pericardial heart valve of Tetralogy of Fallot.
    • ICMR ( 2023-2026): Establishment of microparticle as a liquid biopsy tool for post-traumatic stress disorders (PTSD).
    • DBT (2017-2022): Autophagy regulation of microglia/ macrophage activation followed by Japanese encephalitis viral infection.
    • Dr. Lokendra Kumar Sharma
    • ICMR (2020-2023):Targeting mitophagy in breast carcinogenesis through mitochondrial-mediated mechanisms.
    • DST (2019-2022): Investigation of metastatic potential of mitochondria and associated mechanisms using trans-mitochondrial cybrids. Funded by SERB-Department of Science & Technology
    • Dr. Santosh Verma
    • DBT- (2020-2022): Identifying therapeutic targets for blocking infection of highly pathogenic SARS-CoV-2 at an early stage: developing novel screening assay with minimal bio-hazard risk. Funded by DBT under DBT-BIRAC COVID-19 Research Consortium