Department of Cardiovascular & Thoracic Surgery

INDEPENDENT AND COLLABORATIVE ON-GOING PROJECTS

1. Quadricuspid aortic valve with rupture of sinus valsalva in RA –First report in world with review of literature of 7 years follow-up. Gupta N.K

2. Gupta NK, Sarkar PK. CABG in anomalous coronary arterial pattern- Case report and review of literature.

3. Partial A-V canal defect with Turner Mosaic Syndrome –A rare association. Gupta N.K., Phadke S.

4. Impact of use of phosphodistrase inhibitors in cyanotic heart disease. Gupta N.K., Tripathi MK

5. Postoperative outcome in patients with near inoperable pulmonary vascular disease in Left to Right shunts in children. Gupta N.K.,

6. Right Thoracotomy in congenital heart disease. Gupta N.K., Kapoor A., Singh PK 6-year follow-up in young adolescents with composite stentless porcine valved conduit of bovine pericardium (Biocor® St. Jude Inc.) in pulmonary position. Nirmal Gupta, Tanveer Husssain

7. Spontaneous intracerebral hemorrhage in young patients – Single institutional experience Nirmal Gupta, Rajkumar, Smaeer Kalra

8. How to Do it: Pericardial Strip Suspension Technique for Complete Preservation of Sub-mitral Apparatus. Nirmal Gupta

9. Malignant Rhabdomyosarcoma Mimicking Chest wall Hemangioma Gupta NK New Technique: Pericardial Patch Augmentation of Tricuspid Septal Leaflet Nirmal Gupta

10. Narrow Aortic Root in Adult Patients: Role of Konno’s Aorto-ventriculoplasty Nirmal Gupta

11. Analysis of the Association of Renal Dysfunction and Outcome in Cardiac Surgery: Normothermic Vs. Hypothermic Bypass in Children: Estimated Glomerular Filtration and Plasma Creatinine Level as Measures of Renal Function Nirmal Gupta Gauranga Mazumdar

12. Study of pericardial fluid using H-NMR in cyanotic and Acyanotic heart diseases. Gupta NK, Tripathi P, Khetrapal CL.

13. Study of predictive value of prognosis with lactic academia in preoperative cyanotic heart disease children using H-NMR technique. Gupta NK, Tripathi P, Khetrapal CL.

14. Study of chemical composition of valve diseased due to rheumatic fever and congenital heart diseases. Gupta NK, Tripathi P, Roy R. Khetrapal CL.

15. Analysis of the Association of Renal Dysfunction and Outcome in Cardiac Surgery: Normothermic Vs. Hypothermic Bypass in Children. Gupta NK, Mazumdar G International randomized, double blind clinical study evaluating the efficacy and safety of clopidogrel 0.2mg/kg once daily vs placebo in neonates and infants with cyanotic congenital heart disease and palliated with a systemic-to-pulmonary artery (modified Blalock Taussig Shunt) Gupta NK (Principal investigator).

1. Study of RV function in patients with rheumatic heart valve disease. Started in August 2007; completed. Paper published.

2. Study of RV function by echocardiography and Nuclear medicine imaging in patients with low ejection fraction undergoing CABG.

3. Does apoptosis play a role in right ventricular dysfunction in rheumatic valvular heart disease? Project completed.

4. Assessment of neurological injury before and after the open-heart surgery with cardiopulmonary bypass for the repair of congenital heart defects in children. Project completed. Manuscript being written.

5. Role of soluble c AMP in the development of right ventricular hypertrophy in patients with pulmonary arterial hypertension. Project completed.

1. Evaluation of SPAC valve made of fresh autologous pericardium at pulmonary position in patients of tetralogy of Fallot requiring transannular patch. Principal Investigator: Dr. Shantanu Pande

2.PET CT evaluation of FDG uptake by monocusp and trileaflet FAP valve at pulmonary position Principal Investigator: Dr. Shantanu Pande

3.Non invasive assessment of right ventricular function by radionucilde angiography in CABG patients. Principal Investigator: Dr. Amitabh Arya Co-Investigator: Dr. Shantanu Pande

4. Assessment of neurological injury before and after the open-heart surgery with cardiopulmonary bypass for the repair of congenital heart defects in children. Principal Investigator: Dr. Puneet Goyal Co-Investigator: DR. Shantanu Pande

5. Does apoptosis causes right ventricular dysfunction in rheumatic valvular heart disease? Principal Investigator: Dr. Shantanu Pande

6. Preoperative right ventricular function in valvular heart disease; indices, incidence and prognosis Principal Investigator: Dr. Shantanu Pande

Research Projects as Principal Investigator during the year under review.

1.Data analysis: Concomitant surgeries in OHS patients.

2.Data acquisition and analysis– reverse remodeling in AS/MS/AS+MS patients under 40years.

Research Projects as Co-investigator

1.Co-investigator in the first Made in India Biological Valve (Merrill), grantedApproval April 2018.

2.Co-investigator: development of Patients controlled INR Algorithm in association with Dept. of Fundamental mathematics IIT Kanpur.

1. PI from the institute of the Multicentric trial on Role of autologous stem cells in patients with critical chronic limb ischemia: funded by BDT, India. Project completed.

2. Part of the international STICHtrial for CABG in patients with poor LV function, funded by NIH USA. Project completed. Two papers published in New Eng J Med.

3. PI form institute of the International, multicentric trial of off pump versus on pump CABG trial (CORONARY), funded by Canadian Institute of Health Research, Mc Master University, Canada

4. PI from the institute of International, multicentric trial of steroids in cardiac surgery (SIRS trial) funded by Canadian Institute of Health Research, Mc Master University, Canada

5. Co-PI of the International multicenteric trial POISE 2, funded by Canadian Institute of Health Research, Mc Master University, Canada

6. PI from the institute of the trial on role of a new oral anticoagulant in patients with deep vein thrombosis, funded by Di-ichi Sankyo, Japan.

7. Co-PI in project on Pharmacogentics of anticoagulant therapies. Project funded by DBT, Govt of India Total funding Rs. 2344000.00

8. Co-Pi in the project on Role of sarcomeric gene mutation in left ventricular dysfunction. Project funded by ICMR.

9. Part of stem cell group of SGPGIMS and co-investigator in project of up gradation of stem cell facility at SGPGI, Funded by DBT, Govt. of India

OTHER RESEARCH PROJECTS (WITH-OUT OUTSIDE FUNDING)

1. Role of MRI and nuclear scan in evaluation of left ventricular function in patients undergoing CABG (Part of Thesis of MD Student in Department of Radiology, was a co-guide)

2. Role of Early discharge in resource utilization in cardiac surgery: an audit. (Part of thesis of student in Department of Hospital Administration, was a co-guide)

3. Can pre-treatment with statins prevent myocardial damage associated with open heart surgery?

4. Evaluation of St Jude Medical Regent aortic prosthesis in patients undergoing AVR and having small aortic root

5. Audit of aortic valve replacement in presence of severe PAH in SGPGI

6. GFR estimation in patients undergoing heart surgery: determinants of post-operative renal dysfunction

7. Stem cell therapy for myocardial regeneration

8. Evaluation of St Jude Medical Regent aortic prosthesis in patients undergoing AVR and having small aortic root

9. Influence of severe pulmonary hypertension in patients undergoing combined aortic and mitral valve replacement

10. Role of ‘Penegra’ in severe PAH caused by acquired heart valve disease

11. Audit of double valve replacement at SGPGI

12. Study of neurocognitive dysfunction in patients undergoing off-pump CABG and correlation with MRI findings

1. STICH Trial Co-investigator (Lead Surgeon): Dr. Shantanu Pande PI Prof Nakul Sinha

2. Off and on pump coronary bypass grafting trial (CORONARY) Co-investigator (Lead Surgeon): Dr. Shantanu Pande PI Dr. S K Agarwal

3. Role of stem cell therapy in chronic critical limb ischaemia Co-Principal investigator: Dr. Shantanu Pande PI Dr. S K Agarwal

4. Role of steroids in cardiac surgery in modulating inflammatory response (SIRS) Co-investigator: Dr. Shantanu Pande PI Dr. S K Agarwal

5. Role of a new oral anticoagulant in patients with deep vein thrombosis Co-investigator: Dr. Shantanu Pande PI Dr. S K Agarwal

6. Pharmacogenetics of oral anticoagulants Co-investigator: Dr. Shantanu Pande PI Prof. Balraj Mittal