Research

Research Projects - Intramural

  • Role of HDAC2 on P-GP expression in steroid resistant nephritic syndrome patients. 2016: completed and published Frontier’s Pharmacology.
  • Association of anti-phospholipase A2 receptor and PLA2R polymorphism with clinical status in membranous nephropathy. 2015 (Ongoing)
  • Regulatory , Effector and Cytotoxic T cells profile in chronic renal allograft dysfunction. IEC-2012117-Phd -63 Comparative profiles of Th1, Treg and Th17 cell in basiliximab vs ATG induced renal transplant recipient patient. IEC-2013-46-MD-69
  • Expression of T-regulatory cells in patients with steroid sensitive and steroid resistant nephrotic syndrome.(REF.NO.PGI/DIR/RC/186/2011, IEC Code No:A-15:pgi/IMP/IEC/53/18.02.2011) (Project completed and published)
  • MDR-1 gene polymorphism in patients with steroid sensitive and steroid resistant nephrotic syndrome(Ref. Code: PGI/DIR/RC/1177/2009, IEC Code No:A-03: PGI/IMP/EC/ 53/13.08.2008) Completed and published in NDT 2011)
  • Effect of Tacrolimus on P-glycoprotein Expression on Different T cells Lymphocytes in Steroid Resistant Nephrotic Syndrome Patients. Intramural grant 2013-2015 Completed . Published one paper in Cytokine
  • Changes in Th1 and T-reg cell profiles in renal transplant recipient with and without Basiliximab induction2012-2015. Completed Published one paper in Nephrology
  • Role of alpha-ketoanalogues in retarding progression of chronic kidney disease.AS
  • Association of Levels of FGF-23, Klotho, PTH with Dietary Phosphorus in Chronic Kidney Disease Stages 1 and 2.
  • Enhanced expression of β-D-galactosidase in probiotic strains of Lactic Acid Bacteria against Lactose Intolerance.
  • Role of alpha-ketoanalogues in retarding progression of chronic kidney disease
  • NGAL as early biomarker of Nephropathy in diabetic patients and effect of RAAS blockade(2015-2017).
  • Assessment of allograft function using diffusion weighted magnetic resonanceimaging in kidney transplant patients (2012-14)
  • Title: To evaluate the role of Th1/Th2 and Th17/Treg balance in normal pregnancy as well aspreeclampsia associated podoctyuria and its association with other proteinuric renal diseases (2018 till date)
  • Role of biomarkers in predicting contrast-induced acute kidney injury in critically ill patients: a prospective observational study [ May 2015 – Apr 2017]
  • Renal outcome of acute kidney disease in critically ill patients: a prospective observational study [Jun 2018 – Jun 2020]

Research Projects - Extramural

  • Role of vascular endothelial growth factor on acute renal allograft rejection. ICMR funding IEC 2014-205-EMP-EXP PGI/BE/895/2014- ICMR –no.5/4/7-7/2014-NCD-II
  • Evaluation of clinical and environmental factors associated with chronic kidney disease of unknown origin (CKDu) in India. IEC 2017-92-IP-97 PGI/BE/501/2017
  • To establish a registry of epidemiology, clinical characteristics and outcomes of AKI in India. IEC 2017-113-EMP-97/PGI/BE/478/2017
  • A Randomized, Double-blind, event-driven, Placebo-Controlled, Multicenter Study of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Subjects with Type 2 Diabetes Mellitus and Diabetic Nephropathy (CREDENCE Study- IN00132).
  • Indian Chronic Kidney Disease (ICKD) Study( DBT funding)-IEC 2015-92-EMP-EXP PGI/BE/607/2016 SGPGIMS site.
  • Therapeutic Evaluation of Steroids in IgA Nephropathy Global low dose study (TESTING study INDIA) (GI-R-01-2011)-SGPGIMS site
  • Identification of microorganism in culture negative peritonitis by molecular technique. Extramural Grant.Baxter International Asia pacific study grant (IEC Code No: A-35:PGI/EMP/53/18.02.2011).
  • Role of Multi drug resistance P-glycoprotein, MRP-1 protein and MDR-1 polymorphism in steroid resistance and steroid sensitive nephrotic syndrome. (ICMR-2010-08620) Funding DHR/GIA/40/2014
  • A randomized , multicentre , parallel, open label , active controlled phase III study to evaluate the clinical efficacy and safety of Kremezin on suppression of progression of chronic kidney disease.(KR-09-03/08/03/Jun/2010, IEC Code No:A-07 PGI/DT/IEC/51/16.07.2010)
  • Comparative profiles of Th1 , Th2 , Treg and Th17 cell in basiliximab versus ATG induced renal transplant recipients. Extramural Grant