Peer-reviewed Publications (Total Number 40):

(Cumulative IF>200, Citations-2650, h-Index-22, i-10 index-30) (https://www.ncbi.nlm.nih.gov/myncbi/121H6JIM8fAkR/bibliography/public/ https://scholar.google.com/citations?user=PK3KvAUAAAAJ&hl=en

 

Most relevant to the current research area (Cancer, aging and neuro-degeneration and women health) (*Corresponding Author)

 

  1. Srivastava, A, Mallik R, Sharma LK*, Rani A, Gupta A, Tiwari M, Mishra P, Singh Diagnostic utility of Synuclein gamma (SNCG) and b-cell Lymphoma 6 (BCL6) as potential non-invasive dual biomarkers for endometriosis. Eur J Obstet Gynecol Reprod Biol. 2025 Oct 19:315:114778. doi: 10.1016/j.ejogrb.2025.114778. Online ahead of print..
  2. Chakravarti B, Rajput S, Srivastava A, Sharma LK, Sinha RA, Chattopadhyay N, Siddiqui A Systematic Review and Meta-Analysis of the Effects of Dietary Isoflavones on Female Hormone-Dependent Cancers for Benefit–Risk Evaluation. October 2024. Phytotherapy Research, DOI: 10.1002/ptr.8358 (IF: 6.1)
  3. Mishra A, Srivastava A, Srivastava A, Sharma LK, Mishra AK, Shrivastava A. Comparative metabolomics of MCF-7 and MCF-7/TAMR identifies potential metabolic pathways in tamoxifen resistance breast cancer cells Am J Transl Res. 2024 Apr 15;16(4):1337-1352. doi: 10.62347/MJLN5908. eCollection 2024 (IF=2.2)
  4. Mathur, S. Srivastava, P. Srivastava, A. Rai, NK. Abbas S, Kumar, A.Tiwari, M. Sharma, LK*.Regulation of metastatic potential by drug repurposing and mitochondrial targeting in colorectal cancer cells. BMC Cancer 24, 323 (2024). https://doi.org/10.1186/s12885-024-12064-5. (IF=4.3).
  5. Tiwari, M*. Srivastava, P. Abbas, S. Jegatheesan, J. Ranjan, A.Sharma, S. Maurya, V.P. Saxena, A.K. Sharma, L.K*. Emerging Role of Autophagy in Governing Cellular Dormancy, Metabolic Functions, and Therapeutic Responses of Cancer Stem Cells. Cells 2024, 13, 447. https://doi.org/10.3390/cells13050447.(IF=6.7)
  6. Yadav P, Bandyopadhayaya S, Soni S, Saini S, Sharma LK, Shrivastava SK, Mandal CC. Simvastatin prevents BMP-2 driven cell migration and invasion by suppressing oncogenic DNMT1 expression in breast cancer cells. Gene. 2023 Jul 11:147636. doi: 1016/j.gene.2023.147636. (IF: 3.913)
  7. Yadav P, Makwana S, Bansal S, Soni S, Mahapatra MK, Bandyopadhayaya S, Tailor R, Shrivastava SK, Sharma LK, Mandal CC. Metformin prevents osteoblast-like potential and calcification in lung cancer A549 cells. J Biochem Mol Toxicol . 2023 Jul 6;e23454. doi: 10.1002/jbt.23454.(IF: 3.568)
  8. Kuldeep, S. Soni, S. Srivastava, A. Mishra, A. Sharma, LK, Mandal CC. Dysregulated cholesterol regulatory genes as a diagnostic biomarker for cancer”. J Gene Med . 2023 Apr;25(4):e3475. doi: 10.1002/jgm.3475. Epub 2023 Feb 5 (eISSN:1521-2254). (IF: 4.15).
  9. Srivastava, A., Srivastava, P., Mathur, S. Mishra S, Abbas S, Gupta A, Mishra P, Tiwari M, Sharma LK*. Analysis of cellular and cell free mitochondrial DNA content and reactive oxygen species levels in maternal blood during normal pregnancy: a pilot study. BMC Pregnancy Childbirth. 2022 Nov 16;22(1):845. doi: 1186/s12884-022-05156-2. PMID: 36384496 PMCID: PMC9670558 (eISSN: 1471-2393)(IF: 3.01).
  10. Srivastava A, Srivastava P, Mathur S, Abbas S, Rai NK, Tiwari S, Tiwari M, Sharma LK*. Lipid metabolism and mitochondria: Cross talk in cancer. Curr Drug Targets. 2021 Aug 24. doi: 10.2174/1389450122666210824144907. PMID: 34431462 (eISSN: 1873-5592) (IF:3.46).
  11. Rai NK, Panjwani G, Ghosh AK, Haque R, Sharma LK*, Analysis of mitochondrial DNA copy number variation in blood and tissue samples of metastatic breast cancer patients (A pilot study). Biochemistry and Biophysics Reports 26 (2021) 100931. DOI: 10.1016/j.bbrep.2021.100931PMID: 33644420 PMCID: PMC7889791 (eISSN: 2405-5808) (IF:2.61).
  12. Abbas S, Singh SK, Saxena AK, Tiwari S, Sharma LK*,Tiwari M*. Role of autophagy in regulation of glioma stem cells population during therapeutic J Stem Cells Regen Med. 2020; 16(2): 80–89. doi:10.46582/jsrm.1602012. PMCID: PMC7772813 PMID: 33414584 (eISSN: 0973-7154). (IF: 0.80).
  13. Rai NK, Mathur S, Singh SK, Tiwari M, Singh VK, Haque R, Tiwari S and Sharma LK*: Differential regulation of mitochondrial complex I and oxidative stress based on metastatic potential of colorectal cancer Oncol Lett 20: 313, 2020 DOI: 10.3892/ol.2020.12176 PMID: 33093922 PMCID: PMC7573887 (eISSN: 1792-1082) (IF: 3.11).
  14. Singh SK, Abbas S, Saxena AK, Tiwari S, Sharma LK*,Tiwari M*. Critical role of 3-dimensional tumorspheres size on experimental outcome. Biotechniques. 2020 Nov;69(5):333-338. doi: 10.2144/btn-2020-0081. PMID: 33000639 (eISSN: 1940-9818 (IF: 1.99).
  15. Tiwari M, Saxena AK, Sharma LK. Loss of INI1 Expression-Understanding the Molecular Basis of Chordoid Meningiomas. Neurol India. 2019 Nov-Dec;67(6):1498-1499. doi: 10.4103/0028-3886.273615. PMID: 31857544 (eISSN: 1998-4022 (IF: 2.11).
  16. Sharma LK*, Tiwari M, Rai N, Bai Y*. Mitophagy activation rescues Leber's Hereditary Optic Neuropathy associated mitochondrial dysfunction and improves cell survival (Hum Mol Genet. 2019 Feb 1;28(3):422-433). doi: 10.1093/hmg/ddy354, PMCID: PMC6489411,PMID: 30304398 eISSN: 1460-2083 (IF: 6.15).
  17. Idowu AJ, Kumar SL, Yidong B, Russel R. Melatonin modulates neuronal mitochondria function during normal ageing in mice. Niger J Physiol Sci. 2017 Dec 30;32(2):145-152. (PMID: 29485634) pISSN:0794-859X (IF: 0.56).
  18. Edmunds LR, Otero PA, Sharma L, D'Souza S, Dolezal JM, David S, Lu J, Lamm L, Basantani M, Zhang P, Sipula IJ, Li L, Zeng X, Ding Y, Ding F, Beck ME, Vockley J, Monga SP, Kershaw EE, O'Doherty RM, Kratz LE, Yates NA, Goetzman EP, Scott D, Duncan AW, Prochownik EV. Abnormal Lipid Processing but Normal Long-Term Repopulation Potential of myc-/- Hepatocytes. Oncotarget. 2016 May 24;7(21):30379-95 (PMID: 27105497)(eISSN: 1949-2553) (IF:6.38).
  19. Mishur RJ, Khan M, Munkácsy E, Sharma L, Bokov A, Beam H, Radetskaya O, Borror M, Lane R, Bai Y, Rea Mitochondrial metabolites extend lifespan. Aging Cell. 2016 Apr;15(2):336-48.] (PMID: 26729005) (ISSN: 1474-9726) (IF: 9.30)
  20. Edmunds LR, Sharma L, Wang H, Kang A, d'Souza S, Lu J, McLaughlin M, Dolezal JM, Gao X, Weintraub ST, Ding Y, Zeng X, Yates N, Prochownik EV. c-Myc and AMPK Control Cellular Energy Levels by Cooperatively Regulating Mitochondrial Structure and Function. PLoS One. 2015 Jul 31;10(7):e0134049. doi: 10.1371/journal.pone.0134049. eCollection (PMID:26230505) (eISSN: 0304-4165) (IF: 3.234).
  21. Wang H, Sharma L, Lu J, Finch P, Fletcher S, Prochownik EV. Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion. Oncotarget. 2015 Jun 30;6(18):15857-70. PMID: 26036281. (eISSN: 1949-2553) (IF:6.63).
  22. Meenakshi Tiwari, Lokendra K. Sharma, Ajit K Saxena, Madan M. Godbole. Interaction Between Mitochondria and Caspase: Apoptotic and Non-Apoptotic Roles. Cell Biology Special Issue: Mitochondria: Implications in Human Health and Diseases 2015; 3(2-1): 22-30. Published online March 18, 2015. (eISSN:2330-0183).
  23. Lokendra Kumar Sharma*, Meenakshi Tiwari, Santosh Kumar Mishra. Mitochondrial Alteration: A Major Player in Carcinogenesis.Cell Biology Special Issue: Mitochondria: Implications in Human Health and Diseases. 2015; 3(2-1): 8-16. Published online February 10, 2015. (eISSN:2330-0183).
  24. Edmunds LR, Sharma L, Kang A, Lu J, Vockley J, Basu S, Uppala R, Goetzman ES, Beck ME, Scott D, Prochownik EV. c-Myc programs fatty acid metabolism and dictates acetyl CoA abundance and fate. J Biol Chem. 2014 Sep 5; 289(36):25382-92. PMID: 25053415.(eISSN 1083-351X) (IF:5.15).
  25. Tiwari M, Sharma LK, Vanegas D, Callaway DA, Bai Y, Lechleiter JD, Herman B. A Non Apoptotic Role For Caspase-2: Modulation of Autophagy. Autophagy. 2014 Jun;10(6):1054-70. doi: 10.4161/auto.28528. PMID:24879153. (eISSN: 1554-8635) (IF: 16.01).
  26. Li H*, Kumar Sharma L*, Li Y*, Hu P, Idowu A, Liu D, Lu J, Bai Y. Comparative bioenergetic study of neuronal and muscle mitochondria during aging. (* Joint first authors) Free Radic Biol 2013 Apr 30;63C:30-40. (PMID: 23643721) (eISSN: ISSN: 0891-5849) (IF: 7.37).
  27. Sharma LK, Milstein AC, Bai Tumorigenesis: A Mitochondrial Story J Carcinogene Mutagene 2012, 3:2. (ISSN: 2157-2518)( IF: 3.44).
  28. Zhang C, Huang VH, Simon M, Sharma LK, Fan W, Haas R, Wallace DC, Bai Y, Huang T. Heteroplasmic Mutations of the Mitochondrial Genome Cause Paradoxical Effects on Mitochondrial Functions. FASEB J. 2012 Dec;26(12):4914-24. (PMID:22925728). (eISSN: ISSN: 1530-6860). (IF: 5.19)
  29. Sharma LK, Fang H, Liu J, Vartak R, Deng J, Bai Y. Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation. Hum Mol Genet. 2011 Dec 1;20(23):4605-16. (PMID: 21890492). (e ISSN 1460-2083) (IF: 6.15)
  30. Li Y, Li HZ, Hu P, Deng J, Banoei MM, Sharma LK, Bai Y. Generation and bioenergetic analysis of cybrids containing mitochondrial DNA from mouse skeletal muscle during aging. Nucleic Acids Res. 2010 Apr;38(6):1913-21. (PMID: 20022917). (eISSN: 1362-4962) (IF: 16.97)
  31. Chavez AO, Kamath S, Jani R, Sharma LK, Monroy A, Abdul-Ghani MA, Centonze VE, Sathyanarayana P, Coletta DK, Jenkinson CP, Bai Y, Folli F, DeFronzo RA, Tripathy D. Effect of short-term free fatty acid elevation on mitochondrial function in skeletal muscle of healthy individuals. J Clin Endocrinol Metab. 2010 Jan;95(1):422-9. (PMID: 19864449). (eISSN: 1945-7197). (IF:5.95)
  32. Lu J, Sharma LK, Bai Y. Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis. Cell Res. 2009 Jul;19(7):802-15. (PMID: 19532122). (eISSN: 1748-7838). (IF: 25.61)
  33. Sharma LK, Lu J, Bai Mitochondrial respiratory complex I: structure, function and implication in human diseases. Curr Med Chem.

2009;16(10):1266-77. (PMID: 19355884). (eISSN:0929-8673) (IF: 4.53)

  1. Park JS*, Sharma LK*, Li H, Xiang R, Holstein D, Wu J, Lechleiter J, Naylor SL, Deng JJ, Lu J, Bai Y. A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis. Hum Mol Genet. 2009 May 1;18(9):1578-89. (*Joint first authors) (PMID:19208652) (e ISSN 1460-2083). (IF:6.15)

Other Publications:

  1. V Kumar, S Mishra, R Sharma, J Agarwal, U Ghoshal, T Khanna, LK Sharma, SK Verma, P Mishra, S Tiwari Development of RNA-based assay for rapid detection of SARS-CoV-2 in clinical samples. Intervirology 2022 Feb 22;1-7. doi: 10.1159/000522337. (IF:1.76)
  2. Yadav, S., Khandpur, S., Yadav, YS. Goel, MM. Singh, U. Natu, SM. Negi, MPS. Sharma LK. & Tiwari S. Model for Early Prediction of Preeclampsia: A Nested Case Controlled Study in Indian J Obstet Gynecol India 72, 299–306 (2022). https://doi.org/10.1007/s13224- 021-01511-z. (IF: 0.725)
  3. Mishra MK, Chaturvedi P, Singh R, Singh G, Sharma LK, Pandey V, Kumari N, Misra P. Overexpression of WsSGTL1 Gene of Withania somnifera Enhances Salt Tolerance, Heat Tolerance and Cold Acclimation Ability in Transgenic Arabidopsis Plants. PLoS One. 2013 Apr 30;8(4):e63064. doi: 10.1371/journal.pone.0063064. Print 2013. (PMID: 23646175) (eISSN: 0304-4165) (IF: 3.23)
  4. Madina BR, Sharma LK, Chaturvedi P, Sangwan RS, Tuli R. Purification and characterization of a novel glucosyltransferase specific to 27beta-hydroxy steroidal lactones from Withania somnifera and its role in stress responses. Biochim Biophys 2007 Sep;1774(9):1199-207. (PMID: 17704015). (ISSN: 0304-4165) (IF: 3.03).
  5. Sharma LK, Madina BR, Chaturvedi P, Sangwan RS, Tuli R. Molecular cloning and characterization of one member of 3beta-hydroxy sterol glucosyltransferase gene family in Withania somnifera. Arch Biochem Biophys. 2007 Apr 1;460(1):48-55. (PMID: 17324374). (ISSN: 0003- 9861) (IF: 4.01).
  6. Madina BR, Sharma LK, Chaturvedi P, Sangwan RS, Tuli R. Purification and physico-kinetic characterization of 3beta-hydroxy specific sterol glucosyltransferase from Withania somnifera (L) and its stress response. Biochim Biophys Acta. 2007 Mar;1774(3):392-402. (PMID: 17293176). (ISSN: 0304-4165) (IF: 3.03).

 

GenBank Accessions: DQ356887, DQ356888, DQ356889, EF370405

 

Book Chapter:

  • Tiwari, M. , Sharma, L. K., Saxena, A. K. . Potential Role of Cancer Stem Cells in Glioblastoma: A Therapeutic Aspect. In: Glioblastoma - Current Evidences [Working Title] [Internet]. London: IntechOpen; 2022. doi: 10.5772/intechopen.106332.
  • Rai N.K., Singh S.K., Tiwari M., Sharma L.K*. (2020) Implications of Nanotechnology in Cancer Diagnostics and Therapeutics. In: Thangadurai D., Sangeetha J., Prasad R. (eds) Functional Bionanomaterials. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3- 030-41464-1_12. (*Corresponding Author).
  • Lokendra Kumar Sharma*, Meenakshi Tiwari, Neeraj Kumar Rai. Role of soy and its products in cancer. Book: Soy Protein: Properties, Health Effects and Research Advances 2017, Chapter 6. Nova Publications, USA. (*Corresponding Author).
  • Meenakshi Tiwari, Lokendra K. Sharma, Madan M. Godbole. Enhancement of Cell Death in High-Grade Glioma Cells: Role of N-(4- Hydroxyphenyl) Retinamide-Induced Autophagy,, Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. 2014, Volume 1: Molecular Mechanisms, Chapter 16. 235-250.

Abstract published in proceedings:

  • Lia R. Edmunds, Lokendra Sharma, Peter Anthony Otero, Sonia D'Souza, James M. Dolezal, Xuemei Zeng, Ying Ding, Fei Ding, Megan E. Beck, Lisa E. Kratz, Jerry Vockley, Eric Goetzman, Donald Scott, Nathan Yates, Andrew W. Duncan, Edward V. Prochownik. Novel hepatic phenotypes caused by conditional c-Myc deletion. [abstract]. In: Proceedings of the AACR Special Conference: Metabolism and Cancer; Jun 7- 10, 2015; Bellevue, WA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(1_Suppl):Abstract nr B25.
  • Sharma LK, Tiwari M, Bai Y . Rescue of mitochondrial functions by activation of selective autophagy (mitophagy) in leber’s hereditary optic neuropathy (lhon). Journal of World Mitochondria Society 2015 (2015)Vol 1, No 2 (2015).
  • Lokendra Sharma and Yidong Bai. Alterations in metabolic profiling of Leber's Hereditary Optic Neuropathy. Pathobiology of Aging & Age- related Diseases 2015, 5: 30765 - http://dx.doi.org/10.3402/pba.v5.30765. Barshop Symposium on Aging, Metabolism and Aging: From Molecular Physiology to Systems Biology, Mayan Ranch, Bandera, Texas, United States. October 1518, 2015.
  • Meenakshi Tiwari, Lokendra Sharma, Difernando Vanegas, Yidong Bai, and Brian Herman. Role of caspase-2 as an endogenous repressor of autophagy. Pathobiol Aging Age Relat Dis. 2012; 2: 10.3402/pba.v2i0.20276. Published online 2012 Dec 31. doi: 10.3402/pba.v2i0.20276.