Resume
Name: Dr. Ravi Shankar Singh
Fields of Interest
I have long been fascinated by helicases and their role in various diseases. We recently published a report on the dual functionality of DEAD-box helicase-41 (DDX41) in innate immunity, demonstrating that a DDX41 (R525H) mutation causes MDS/AML (Cell Report, 2022). We also reported that DDX41 helicase facilitates homologous recombination repair by potentially resolving R-loops (Nucleic Acids Research 2026). My current work focuses on using advanced techniques such as CRISPR-Cas9, proximity and self-labelling, mass spectrometry, and high-throughput microscopy to better understand the direct roles of helicases in kidney disease, exosome biogenesis, and miRNA packaging in exosomes, and to use these insights for the development of non-invasive biomarkers and personalized therapeutics in clinical settings.
Professional History and Achievements
After completing my Ph.D. in Molecular Medicine and Biotechnology at SGPGIMS in Lucknow, I completed 7.5 years of postdoctoral training at the University of Saskatchewan in Canada and the University of Utah in the USA. Throughout my research career, I have worked extensively on kidney diseases, the biochemical properties of helicases, and the molecular and cellular mechanisms underlying inflammatory diseases. I am the author or co-author of several peer-reviewed publications.
My Master’s program is sponsored by JNU-CBEE, and I have qualified for GATE, NET-LS, and ICMR-JRF, which also supported my PhD. I was honoured to receive the Best Global Research Award on Innate Autoimmunity and Cancer from Dialogue India on August 6, 2022, presented by General (Dr.) V. K. Singh (Retd.), the Union Minister for Civil Aviation, Government of India. Additionally, I received a travel grant to attend the Keystone Symposium in Taipei, Taiwan, in 2019, won the Best Poster Award from PSFaM in 2019, and obtained the Publication Fund Award, among other accolades. Recently, on the day of the departmental foundation ceremony for Molecular Medicine & Biotechnology at SGPGIMS, I was recognized as the best teacher by student votes. My contributions to kidney diseases and innate immunity have been widely recognized and featured in both national and international media.