Publications

    Total Publications:118

    Total Citations: 20837

    h-index: 44

    i10-index:87

     

    Publications:

    1. Gupta P, Tewari A, Rajak S, Shahi A, Yadav A, Raza S, Sinha RA*. Dehydroepiandrosterone (DHEA)-induced autophagy protects against lipotoxicity in hepatic cells. Mol Cell Endocrinol. 2025 May 21:112584. *Corresponding author.
    2. Chakravarti B, Tomar MS, Qais FA, Raza S, Abdullah KM, Sharma G, Tewari A, Yadav A, Gupta P, Chattopadhyay N, Shrivastava A, Sinha RA, Siddiqui JA. Alpha lipoic acid modulates metabolic reprogramming in breast cancer stem cells enriched 3D spheroids by targeting phosphoinositide 3-kinase: In silico and in vitro insig hts. Biomed Pharmacother. 2025 Jun;187:118121.
    3. Raza S, Tewari A, Rajak S, Gupta P, Sinha RA*. Extracellular RNA mediates iron-induced toxicity and inflammatory signalling in hepatic cells. Toxicol Rep. 2025 Jun;14:102002. *Corresponding author.
    4. Rajak S, Shah A, Yadav A, Shahi A, Raza S, Singh MM, Chaturvedi CP, Sinha RA*. Inhibition of histone methyltransferase G9a aggravates phenotypic severity of hepatic lipotoxicity in non-alcoholic steatohepatitis (NASH). Biochem Biophys Res Commun. 2025 Jan;743:151171. *Corresponding author.
    5. Sinha RA, Bruinstroop E, Yen PM. Actions of thyroid hormones and thyromimetics on the liver. Nat Rev Gastroenterol Hepatol. 2025 Jan;22(1):9-22.
    6. Singh A, Anjum B, Naz Q, Raza S, Sinha RA, Ahmad MK, Mehdi AA, Verma N. Night shift-induced circadian disruption: links to initiation of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and risk of hepatic cancer. Hepatoma Res. 2024;10:46.
    7. Chakravarti B, Rajput S, Srivastava A, Sharma LK, Sinha RA, Chattopadhyay N, Siddiqui JA. A Systematic Review and Meta-Analysis of the Effects of Dietary Isoflavones on Female Hormone-Dependent Cancers for Benefit-Risk Evaluation. Phytother Res. 2024 Oct 31. doi: 10.1002/ptr.8358.
    8. Singh J, Hussain Y, Meena A, Sinha RA, Luqman S. Asiatic acid impedes NSCLC progression by inhibiting COX-2 and modulating PI3K signaling. FEBS Lett. 2024 Oct 11. doi: 10.1002/1873-3468.15027.
    9. Singh G, Singh K, Sinha RA, Singh A, Khushi, Kumar A. Japanese encephalitis virus infection causes reactive oxygen species-mediated skeletal muscle damage. Eur J Neurosci. 2024 Sep;60(5):4843-4860.
    10. Shahi A, Yadav A, Rajak S, Raza S, Tewari A, Gupta P, Sinha RA*. Liver-specific thyroid hormone receptor-β agonism alleviates alcoholic steatohepatitis (ASH) in mice. Biochem Biophys Res Commun. 2024 Nov 19;734:150742. *Corresponding author.
    11. Sinha RA*.Thyroid Hormone-Mediated Selective Autophagy and Its Implications in Countering Metabolic Dysfunction-Associated Steatotic Liver Disease. Endocrinol Metab (Seoul). 2024 Oct;39(5):686-692. *Corresponding author.
    12. Raza S, Rajak S, Yen PM, Sinha RA*. Autophagy and hepatic lipid metabolism: mechanistic insight and therapeutic potential for MASLD. NPJ Metab Health Dis. 2024;2(1):19. *Corresponding author.
    13. Raza S, Siddiqui JK, Srivastava A, Chattopadhyay N, Sinha RA*, Chakravarti B. Targeting autophagy in the breast tumor microenvironment: The Cancer stem cell perspective. Autophagy Reports. 2024 Jun 24;3(1):27694127.2024.2358648. *Corresponding author.
    14. Sinha RA*. Targeting Nuclear Receptors for NASH/MASH: From Bench to Bedside. Liver Research. 2024 Mar;8(1):34-45. *Corresponding author.
    15. Saxena P, Srivastava J, Rai B, Tripathy NK, Raza S, Sinha RA, Gupta R, Yadav S, Nityanand S, Chaturvedi CP. Elevated senescence in the bone marrow mesenchymal stem cells of acquired aplastic anemia patients: A possible implication of DNA damage responses and telomere attrition. Biochim Biophys Acta Mol Basis Dis. 2024 Jan 17;1870(3):167025.
    16. Hussain Y, Singh J, Meena A, Sinha RA, Lukman S. Escin-sorafenib synergy up-regulates LC3-II and p62 to induce apoptosis in hepatocellular carcinoma cells. Environmental Toxicology. 2024 Feb;39(2):840-856.
    17. Sinha RA* and Yen P.M. Metabolic messengers: Thyroid Hormones. Nature Metabolism. 2024 (In Press). *Corresponding author.
    18. Raza S, Shahi A, Medhe P, Tewari A, Gupta P, Rajak S, Chakravarti B, Sinha RA*. Fructose-induced perturbation in cellular proteostasis via RPS6KB1 promotes hepatic steatosis. Biochim Biophys Acta Mol Cell Res. 2024 Jan;1871(1):119597. *Corresponding author.
    19. Raza S, Rajak S, Singh R, Zhou J, Sinha RA, Goel A. Cell-type specific role of autophagy in the liver and its implications in non-alcoholic fatty liver disease. World J Hepatol. 2023 Dec 27;15(12):1272-1283.
    20. Singh J, Hussain Y, Meena A, Luqman S, Sinha RA. Molecular regulation of autophagy and suppression of protein kinases by aescin, a triterpenoid saponin impedes lung cancer progression. Int J Biol Macromol. 2023 Aug 12;252:126328.
    21. Hussain Y, Meena A, Sinha RA. Gossypol synergises antiproliferative effect of sorafenib in metastatic lung cancer cells following Chou-Talalay algorithm. Toxicol In Vitro. 2023 Aug 21;93:105666.
    22. Hussain Y, Chaudhary J, Meena A, Sinha RA, Lukman S. Escin enhanced the efficacy of sorafenib by autophagy-mediated apoptosis in lung cancer cells. Phytotherapy Research. 2023 Oct;37(10):4819-4837.
    23. Tewari A, Rajak S, Raza S, Gupta P, Chakravarti B, Shrivastava J, Chaturvedi CP, Sinha RA*. Targeting Extracellular RNA Mitigates Hepatic Lipotoxicity and Liver Injury in NASH. Cells. 2023 Jul 13;12(14):1845.*Corresponding author.
    24. Sinha RA*. Autophagy: A cellular guardian against hepatic lipotoxicity. Genes. 2023 Feb 23;14(3):553. *Corresponding author.
    25. Chakravarti B, Siddiqui JA, Sinha RA*, Raza S. Targeting autophagy and lipid metabolism in cancer stem cells. Biochemical Pharmacology. 2023 Jun;212:115550. *Corresponding author.
    26. Rajak S, Tewari A, Raza S, Gupta P, Chakravarti B, Tripathi M, Singh BK, Yen PM, Goel A, Ghosh S, Sinha RA*. Pharmacological inhibition of CFTR attenuates nonalcoholic steatohepatitis (NASH) progression in mice. Biochemica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2023 Apr;1869(4):166662. *Corresponding author.
    27. Benjamin M, Malakar P, Sinha RA, Nasser MW, Batra SK, Siddiqui JA, Chakravarti B. Molecular signaling network and therapeutic developments in breast cancer brain metastasis, Adv Cancer Biol Metastasis. 2023 Jul;7:100079.
    28. Tripathi M, Singh BK, Zhou J, Tikno K, Widjaja A, Sandireddy R, Arul K, Abdul Ghani SAB, Bee GGB, Wong KA, Pei HJ, Shekeran SG, Sinha RA, Singh MK, Cook SA, Suzuki A, Lim TR, Cheah CC, Wang J, Xiao RP, Zhang X, Chow PKH, Yen PM. Vitamin B(12) and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation. Journal of Hepatology. 2022; 77:1246-1255.
    29. Tripathi M, Singh BK, Liehn EA, Lim SY, Tikno K, Castano-Mayan D, Rattanasopa C, Nilcham P, Abdul Ghani SAB, Wu Z, Azhar SH, Zhou J, Hernandez-Resendiz S, Crespo-Avilan GE, Sinha RA, Farah BL, Moe KT, De Silva DA, Angeli V, Singh MK, Singaraja RR, Hausenloy DJ, Yen PM. Caffeine prevents restenosis and inhibits vascular smooth muscle cell proliferation through the induction of autophagy. Autophagy. 2022:1-11.
    30. Raza S, Rajak S, Tewari A, Gupta P, Chattopadhyay N, Sinha RA, Chakravarti B. Multifaceted role of chemokines in solid tumors: From biology to therapy. Semin Cancer Biol. 2022; Nov;86(Pt 3):1105-1121.
    31. Raza S, Rajak S, Srivastava J, Tewari A, Gupta P, Chakravarti B, Ghosh S, Chaturvedi CP, Sinha RA*. ULK1 inhibition attenuates telomerase activity in hepatic cells. Biochim Biophys Acta Mol Cell Res. 2022; 1869:119355, *Corresponding author.
    32. Hussain Y, Singh J, Raza W, Meena A, Rajak S, Sinha RA, Luqman S. Purpurin ameliorates alcohol-induced hepatotoxicity by reducing ROS generation and promoting Nrf2 expression. Life Sci. 2022 Nov 15;309:120964.
    33. Rajak S, Raza S, Sinha RA*. ULK1 Signaling in the Liver: Autophagy Dependent and Independent Actions. Front Cell Dev Biol. 2022; 10:836021, *Corresponding author.
    34. Rajak S, Gupta P, Anjum B, Raza S, Tewari A, Ghosh S, Tripathi M, Singh BK, Sinha RA*. Role of AKR1B10 and AKR1B8 in the pathogenesis of non-alcoholic steatohepatitis (NASH) in mouse. Biochim Biophys Acta Mol Basis Dis. 2022; 1868:166319, *Corresponding author.
    35. Chakravarti B, Rajput S, Raza S, Rajak S, Tewari A, Gupta P, Upadhyay A, Chattopadhyay N, Sinha RA*. Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness. Biochim Biophys Acta Mol Basis Dis. 2022; 1868:166455, *Corresponding author.
    36. Rajak S, Raza S, Tewari A, Sinha RA*. Environmental Toxicants and NAFLD: A Neglected yet Significant Relationship. Dig Dis Sci. 2022 Aug;67(8):3497-3507, *Corresponding author.
    37. Zhou J, Singh BK, Ho JP, Lim A, Bruinstroop E, Ohba K, Sinha RA, Yen PM. MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism. Autophagy. 2021; 17:4043-4061.
    38. Zhou J, Tripathi M, Sinha RA, Singh BK, Yen PM. Gut microbiota and their metabolites in the progression of non-alcoholic fatty liver disease. Hepatoma Res. 2021; 7:11.
    39. Zhou J, Sinha RA, Yen PM. The roles of autophagy and thyroid hormone in the pathogenesis and treatment of NAFLD. Hepatoma Res. 2021; 7:72.
    40. Yadav S, Porwal K, Sinha RA, Chattopadhyay N, Gupta SK. Moderate/subclinical calcium deficiency attenuates trabecular mass, microarchitecture and bone growth in growing rats. Biochem Biophys Rep. 2021; 26:101033.
    41. Raza S, Tewari A, Rajak S, Sinha RA*. Vitamins and non-alcoholic fatty liver disease: A Molecular Insight. Liver Research. 2021; 5:62-71. *Corresponding author.
    42. Zhou J, Gauthier K, Ho JP, Lim A, Zhu XG, Han CR, Sinha RA, Cheng SY, Yen PM. Thyroid Hormone Receptor alpha Regulates Autophagy, Mitochondrial Biogenesis, and Fatty Acid Use in Skeletal Muscle. Endocrinology. 2021 Aug 1;162(8).
    43. Raza S, Rajak S, Upadhyay A, Tewari A, Sinha RA*. Current treatment paradigms and emerging therapies for NAFLD/NASH. Front Biosci (Landmark Ed) 2021; 26:206-237, *Corresponding author.
    44. Rajak S, Yen PM, Sinha RA*. MTORC1-dependent crinophagy regulates glucagon content in pancreatic alpha-cells. Autophagy. 2021; 17:3269-3270, *Corresponding author. (JIF=13.3).
    45. Rajak S, Xie S, Tewari A, Raza S, Wu Y, Bay BH, Yen PM, Sinha RA*. MTORC1 inhibition drives crinophagic degradation of glucagon. Molecular Metabolism. 2021; 53:101286, *Corresponding author.
    46. Pal S, Singh M, Porwal K, Rajak S, Das N, Rajput S, Trivedi AK, Maurya R, Sinha RA, Siddiqi MI, Sanyal S, Chattopadhyay N. Adiponectin receptors by increasing mitochondrial biogenesis and respiration promote osteoblast differentiation: Discovery of isovitexin as a new class of small molecule adiponectin receptor modulator with potential osteoanabolic function. Eur J Pharmacol 2021; 913:174634.
    47. Klionsky DJ,…..Sinha RA. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy. 2021; 17:1-382.
    48. Yadav S, Pal S, Singh P, Porwal K, Sinha RA, Kumari N, Chattopadhyay N, Gupta SK. Calcium repletion to rats with calcipenic rickets fails to recover bone quality: A calcipenic "memory". Bone. 2020; 141:115562.
    49. Upadhyay A, Sinha RA*, Kumar A, Godbole MM. Time-restricted feeding ameliorates maternal high-fat diet-induced fetal lung injury. Exp Mol Pathol. 2020; 114:104413, *Corresponding author.
    50. Sinha RA*, Rajak S, Singh BK, Yen PM. Hepatic Lipid Catabolism via PPARalpha-Lysosomal Crosstalk. Int J Mol Sci. 2020; 21 *Corresponding author.
    51. Sinha RA, Bruinstroop E, Singh BK, Yen PM. Thyroid Hormones and Thyromimetics: A New Approach to Nonalcoholic Steatohepatitis? Hepatology. 2020; 72:770-771.
    52. Rajak S, Raza S, Tewari A, Yadav S, Ghosh S, Yen PM, Sinha RA*. Autophagic protein ULK1 regulates FOXM1 signalling in human hepatoma cells. Biochem Biophys Res Commun. 2020; 532:570-575, *Corresponding author.
    53. Rajak S, Iannucci LF, Zhou J, Anjum B, George N, Singh BK, Ghosh S, Yen PM, Sinha RA*. Loss of ULK1 Attenuates Cholesterogenic Gene Expression in Mammalian Hepatic Cells. Front Cell Dev Biol. 2020; 8:523550, *Corresponding author.
    54. Pandey R, Shukla P, Anjum B, Gupta HP, Pal S, Arjaria N, Gupta K, Chattopadhyay N, Sinha RA*, Bandyopadhyay S. Estrogen deficiency induces memory loss via altered hippocampal HB-EGF and autophagy. Journal of Endocrinology. 2020; 244:53-70, *Corresponding author.
    55. Pal S, Porwal K, Rajak S, Sinha RA, Chattopadhyay N. Selective dietary polyphenols induce differentiation of human osteoblasts by adiponectin receptor 1-mediated reprogramming of mitochondrial energy metabolism. Biomed Pharmacother. 2020; 127:110207.
    56. Kumar A, Kalita J, Sinha RA, Singh G, B A, Shukla M, Tiwari S, Dhole TN, Misra UK. Impaired Autophagy Flux is Associated with Proinflammatory Microglia Activation Following Japanese Encephalitis Virus Infection. Neurochem Res. 2020; 45:2184-2195.
    57. Godbole NM, Sinha RA*, Tiwari S, Pawar SD, Dhole TN. Analysis of influenza virus-induced perturbation in autophagic flux and its modulation during Vitamin D3 mediated anti-apoptotic signaling. Virus Research. 2020; 282:197936, *Corresponding author.
    58. Raza S, Rajak S, Anjum B, Sinha RA*. Molecular links between non-alcoholic fatty liver disease and hepatocellular carcinoma. Hepatoma Res. 2019; 5:42. *Corresponding author.
    59. Zhou J, Ng B, Ko NSJ, Fiedler LR, Khin E, Lim A, Sahib NE, Wu Y, Chothani SP, Schafer S, Bay BH, Sinha RA, Cook SA, Yen PM. Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo. Hum Mol Genet. 2019; 28:1971-1981.
    60. Yau WW, Singh BK, Lesmana R, Zhou J, Sinha RA, Wong KA, Wu Y, Bay BH, Sugii S, Sun L, Yen PM. Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy. Autophagy. 2019; 15:131-150.
    61. Widjaja AA, Singh BK, Adami E, Viswanathan S, Dong J, D'Agostino GA, Ng B, Lim WW, Tan J, Paleja BS, Tripathi M, Lim SY, Shekeran SG, Chothani SP, Rabes A, Sombetzki M, Bruinstroop E, Min LP, Sinha RA, Albani S, Yen PM, Schafer S, Cook SA. Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis. Gastroenterology. 2019; 157:777-792 e714.
    62. Upadhyay A, Anjum B, Godbole NM, Rajak S, Shukla P, Tiwari S, Sinha RA*, Godbole MM. Time-restricted feeding reduces high-fat diet associated placental inflammation and limits adverse effects on fetal organ development. Biochem Biophys Res Commun. 2019; 514:415-421, *Corresponding author.
    63. Tan HWS, Anjum B, Shen HM, Ghosh S, Yen PM, Sinha RA*. Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels. Autophagy. 2019; 15:1455-1459, *Corresponding author.
    64. Sinha RA, Bruinstroop E, Singh BK, Yen PM. Nonalcoholic Fatty Liver Disease and Hypercholesterolemia: Roles of Thyroid Hormones, Metabolites, and Agonists. Thyroid. 2019; 29:1173-1191.
    65. Pal S, Maurya SK, Chattopadhyay S, Pal China S, Porwal K, Kulkarni C, Sanyal S, Sinha RA, Chattopadhyay N. The osteogenic effect of liraglutide involves enhanced mitochondrial biogenesis in osteoblasts. Biochem Pharmacol. 2019; 164:34-44.
    66. Minocha E, Sinha RA, Jain M, Chaturvedi CP, Nityanand S. Amniotic fluid stem cells ameliorate cisplatin-induced acute renal failure through induction of autophagy and inhibition of apoptosis. Stem Cell Res Ther. 2019; 10:370.
    67. Sinha RA*, Singh BK, Yen PM. Direct effects of thyroid hormones on hepatic lipid metabolism. Nature Reviews Endocrinology. 2018; 14:259-269, *Corresponding author.
    68. Singh BK, Sinha RA, Yen PM. Novel Transcriptional Mechanisms for Regulating Metabolism by Thyroid Hormone. Int J Mol Sci. 2018; 19.
    69. Sinha R, Yen PM. Cellular Action of Thyroid Hormone. Endotext, South Dartmouth (MA), 2018.
    70. Singh BK, Sinha RA, Tripathi M, Mendoza A, Ohba K, Sy JAC, Xie SY, Zhou J, Ho JP, Chang CY, Wu Y, Giguere V, Bay BH, Vanacker JM, Ghosh S, Gauthier K, Hollenberg AN, McDonnell DP, Yen PM. Thyroid hormone receptor and ERRalpha coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function. Science Signaling. 2018; 11.
    71. J. Zhou, R.A. Sinha#, R. Lesmana, W.W.Y. Yau, P.M. Yen, Pharmacological Inhibition of Lysosomal Activity as a Method For Monitoring Thyroid Hormone-induced Autophagic Flux in Mammalian Cells In Vitro, Methods Mol Biol. 1801 (2018) 111-122. #Co-First author.
    72. Rastogi L, Godbole MM, Sinha RA, Pradhan S. Reverse triiodothyronine (rT3) attenuates ischemia-reperfusion injury. Biochem Biophys Res Commun. 2018; 506:597-603.
    73. Kumar P, Godbole NM, Chaturvedi CP, Singh RS, George N, Upadhyay A, Anjum B, Godbole MM, Sinha RA*. Mechanisms involved in epigenetic down-regulation of Gfap under maternal hypothyroidism. Biochem Biophys Res Commun. 2018; 502:375-381, *Corresponding author.
    74. Bruinstroop E, Dalan R, Cao Y, Bee YM, Chandran K, Cho LW, Soh SB, Teo EK, Toh SA, Leow MKS, Sinha RA, Sadananthan SA, Michael N, Stapleton HM, Leung C, Angus PW, Patel SK, Burrell LM, Lim SC, Sum CF, Velan SS, Yen PM. Low-Dose Levothyroxine Reduces Intrahepatic Lipid Content in Patients With Type 2 Diabetes Mellitus and NAFLD. J Clin Endocrinol Metabolism. 2018; 103:2698-2706.
    75. Zhou J, Chong SY, Lim A, Singh BK, Sinha RA, Salmon AB, Yen PM. Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging. Aging (Albany NY). 2017; 9:583-599.
    76. Sinha RA*, Singh BK, Zhou J, Xie S, Farah BL, Lesmana R, Ohba K, Tripathi M, Ghosh S, Hollenberg AN, Yen PM. Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells. Autophagy. 2017; 13:169-186, *Corresponding author.
    77. Sinha RA*, Singh BK, Yen PM. Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis. Endocrine Reviews. 2017; 38:69-102, *Corresponding author.
    78. Singh BK, Sinha RA, Ohba K, Yen PM. Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy. Mol Cell Endocrinol. 2017; 458:160-168.
    79. Ohba K, Sinha RA, Singh BK, Iannucci LF, Zhou J, Kovalik JP, Liao XH, Refetoff S, Sng JCG, Leow MK, Yen PM. Changes in Hepatic TRbeta Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model. Thyroid. 2017; 27:852-860.
    80. Iannucci LF, Cioffi F, Senese R, Goglia F, Lanni A, Yen PM, Sinha RA*. Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet. Sci Rep. 2017; 7:2023, *Corresponding author.
    81. Farah BL, Sinha RA, Wu Y, Singh BK, Lim A, Hirayama M, Landau DJ, Bay BH, Koeberl DD, Yen PM. Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa). Sci Rep. 2017; 7:44408.
    82. Farah BL, Landau DJ, Wu Y, Sinha RA, Loh A, Bay BH, Koeberl DD, Yen PM. Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia. Mol Genet Metab. 2017; 122:95-98.
    83. Tripathi M, Zhang CW, Singh BK, Sinha RA, Moe KT, DeSilva DA, Yen PM. Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. Cell Death Dis. 2016; 7:e2513.
    84. Sinha RA, Yen PM. Mechanisms for Thyroid Hormone Action in the CNS, in: N. Koibuchi, P.M. Yen (Eds.) Thyroid Hormone Disruption and Neurodevelopment, Springer New York, New York, NY, 2016, pp. 3-21.
    85. Sinha RA, Yen PM. Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD. Cell Biosci. 2016; 6:46.
    86. Singh BK, Sinha RA, Zhou J, Tripathi M, Ohba K, Wang ME, Astapova I, Ghosh S, Hollenberg AN, Gauthier K, Yen PM. Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. J Biol Chem. 2016; 291:198-214.
    87. Ohba K, Leow MK, Singh BK, Sinha RA, Lesmana R, Liao XH, Ghosh S, Refetoff S, Sng JC, Yen PM. Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice. Endocrinology. 2016; 157:1660-1672.
    88. Lim A, Zhou J, Sinha RA, Singh BK, Ghosh S, Lim KH, Chow PK, Woon ECY, Yen PM. Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity. Biochem Biophys Res Commun. 2016; 479:476-481.
    89. Lesmana R, Sinha RA, Singh BK, Zhou J, Ohba K, Wu Y, Yau WW, Bay BH, Yen PM. Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle. Endocrinology. 2016; 157:23-38.
    90. Iannucci LF, Sun J, Singh BK, Zhou J, Kaddai VA, Lanni A, Yen PM, Sinha RA*. Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells. Biochem Biophys Res Commun. 2016; 480:461-467, *Corresponding author.
    91. Farah BL, Landau DJ, Sinha RA, Brooks ED, Wu Y, Fung SYS, Tanaka T, Hirayama M, Bay BH, Koeberl DD, Yen PM. Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency. Journal of Hepatology. 2016; 64:370-379.
    92. Zhou J, Yong WP, Yap CS, Vijayaraghavan A, Sinha RA, Singh BK, Xiu S, Manesh S, Ngo A, Lim A, Ang C, Xie C, Wong FY, Lin SJ, Wan WK, Tan IB, Flotow H, Tan P, Lim KH, Yen PM, Goh LK. An integrative approach identified genes associated with drug response in gastric cancer. Carcinogenesis. 2015; 36:441-451.
    93. Sinha RA*, Singh BK, Zhou J, Wu Y, Farah BL, Ohba K, Lesmana R, Gooding J, Bay BH, Yen PM. Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling. Autophagy. 2015; 11:1341-1357, *Corresponding author.
    94. Kumar P, Mohan V, Sinha RA*, Chagtoo M, Godbole MM. Histone deacetylase inhibition reduces hypothyroidism-induced neurodevelopmental defects in rats. Journal of Endocrinology. 2015; 227:83-92, *Corresponding author.
    95. Zhou J, Farah BL, Sinha RA, Wu Y, Singh BK, Bay BH, Yang CS, Yen PM. Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance. PLoS One 2014; 9:e87161.
    96. Sinha RA, Singh BK, Yen PM. Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism. Trends Endocrinol Metab 2014; 25:538-545.
    97. Sinha RA, Farah BL, Singh BK, Siddique MM, Li Y, Wu Y, Ilkayeva OR, Gooding J, Ching J, Zhou J, Martinez L, Xie S, Bay BH, Summers SA, Newgard CB, Yen PM. Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. Hepatology 2014; 59:1366-1380.
    98. Farah BL, Sinha RA, Wu Y, Singh BK, Zhou J, Bay BH, Yen PM. beta-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liver. PLoS One. 2014; 9:e98155.
    99. Aw DK, Sinha RA#, Xie SY, Yen PM. Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells. Biochem Biophys Res Commun. 2014; 447:569-573, #Co-First author.
    100. Aw DK, Sinha RA#, Tan HC, Loh LM, Salvatore D, Yen PM. Studies of molecular mechanisms associated with increased deiodinase 3 expression in a case of consumptive hypothyroidism. J Clin Endocrinol Metab. 2014; 99:3965-3971, #Co-First Author.
    101. Yap CS, Sinha RA, Ota S, Katsuki M, Yen PM. Thyroid hormone negatively regulates CDX2 and SOAT2 mRNA expression via induction of miRNA-181d in hepatic cells. Biochem Biophys Res Commun. 2013; 440:635-639.
    102. Xie S, Sinha RA#, Singh BK, Li GD, Han W, Yen PM. Resveratrol induces insulin gene expression in mouse pancreatic alpha-cells. Cell Biosci. 2013; 3:47, #Co-First Author. (JIF=7.5).
    103. Singh BK, Sinha RA, Zhou J, Xie SY, You SH, Gauthier K, Yen PM. FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes. J Biol Chem. 2013; 288:30365-30372.
    104. Pal A, Mohan V, Modi DR, Sinha RA, Rastogi L, Kumar P, Godbole MM. Iodine plus n-3 fatty acid supplementation augments rescue of postnatal neuronal abnormalities in iodine-deficient rat cerebellum. Br J Nutr. 2013; 110:659-670.
    105. Zhou J, Chen GB, Tang YC, Sinha RA, Wu Y, Yap CS, Wang G, Hu J, Xia X, Tan P, Goh LK, Yen PM. Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library. BMC Med Genomics. 2012; 5:34.
    106. Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky ML, Cheng SY, Stevens RD, Summers SA, Newgard CB, Lazar MA, Yen PM. Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. J Clin Invest. 2012; 122:2428-2438.
    107. Mohan V, Sinha RA, Pathak A, Rastogi L, Kumar P, Pal A, Godbole MM. Maternal thyroid hormone deficiency affects the fetal neocorticogenesis by reducing the proliferating pool, rate of neurogenesis and indirect neurogenesis. Exp Neurol. 2012; 237:477-488.
    108. Pathak A, Sinha RA, Mohan V, Mitra K, Godbole MM. Maternal thyroid hormone before the onset of fetal thyroid function regulates reelin and downstream signaling cascade affecting neocortical neuronal migration. Cereb Cortex. 2011; 21:11-21.
    109. Babu S, Sinha RA, Mohan V, Rao G, Pal A, Pathak A, Singh M, Godbole MM. Effect of hypothyroxinemia on thyroid hormone responsiveness and action during rat postnatal neocortical development. Exp Neurol. 2011; 228:91-98.
    110. Sinha RA, Pathak A, Mohan V, Babu S, Pal A, Khare D, Godbole MM. Evidence of a bigenomic regulation of mitochondrial gene expression by thyroid hormone during rat brain development. Biochem Biophys Res Commun. 2010; 397:548-552.
    111. Sinha RA, Pathak A, Kumar A, Tiwari M, Shrivastava A, Godbole MM. Enhanced neuronal loss under perinatal hypothyroidism involves impaired neurotrophic signaling and increased proteolysis of p75(NTR). Mol Cell Neurosci. 2009; 40:354-364.
    112. Sinha RA, Khare P, Rai A, Maurya SK, Pathak A, Mohan V, Nagar GK, Mudiam MK, Godbole MM, Bandyopadhyay S. Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model. Int J Dev Neurosci. 2009; 27:377-383.
    113. Tiwari M, Bajpai VK, Sahasrabuddhe AA, Kumar A, Sinha RA, Behari S, Godbole MM. Inhibition of N-(4-hydroxyphenyl)retinamide-induced autophagy at a lower dose enhances cell death in malignant glioma cells. Carcinogenesis. 2008; 29:600-609.
    114. Sinha RA, Pathak A, Mohan V, Bandyopadhyay S, Rastogi L, Godbole MM. Maternal thyroid hormone: a strong repressor of neuronal nitric oxide synthase in rat embryonic neocortex. Endocrinology. 2008; 149:4396-4401.
    115. Kumar A, Sinha RA, Tiwari M, Singh R, Koji T, Manhas N, Rastogi L, Pal L, Shrivastava A, Sahu RP, Godbole MM. Hyperthyroidism induces apoptosis in rat liver through activation of death receptor-mediated pathways. Journal of Hepatology. 2007; 46:888-898.
    116. Tiwari M, Kumar A, Sinha RA, Shrivastava A, Balapure AK, Sharma R, Bajpai VK, Mitra K, Babu S, Godbole MM. Mechanism of 4-HPR-induced apoptosis in glioma cells: evidences suggesting role of mitochondrial-mediated pathway and endoplasmic reticulum stress. Carcinogenesis. 2006; 27:2047-2058.
    117. Shrivastava A, Tiwari M, Sinha RA, Kumar A, Balapure AK, Bajpai VK, Sharma R, Mitra K, Tandon A, Godbole MM. Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway. J Biol Chem. 2006; 281:19762-19771.
    118. Kumar A, Sinha RA, Tiwari M, Pal L, Shrivastava A, Singh R, Kumar K, Kumar Gupta S, Godbole MM. Increased pro-nerve growth factor and p75 neurotrophin receptor levels in developing hypothyroid rat cerebral cortex are associated with enhanced apoptosis. Endocrinology. 2006; 147:4893-4903.

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