Publications

    Total Publications:101

    Total Citations: 17314

    h-index: 39

    i10-index:75

     

    Selected Publications

     

    1. Sinha RA* and Yen P.M. Metabolic messengers: Thyroid Hormones. Nature Metabolism 2023; (Under minor revision, Invited), *Corresponding author (JIF=19.1). 
    2. Hussain Y, Singh J, Meena A, Sinha RA, Lukman S. Escin-sorafenib synergy up-regulates LC3-II and p62 to induce apoptosis in hepatocellular carcinoma cells. Environmental Toxicology. 2023 (In Press). (JIF=4.5). 
    3. Raza S, Shahi A, Medhe P, Tewari A, Gupta P, Rajak S, Chakravarti B, Sinha RA*. Fructose-induced perturbation in cellular proteostasis via RPS6KB1 promotes hepatic steatosis. BiochimBiophys Acta Mol Cell Res. 2023 Sep 22;1871(1):119597. *Corresponding author (JIF=5.1). 
    4. Singh J, Hussain Y, Meena A, Luqman S, Sinha RA. Molecular regulation of autophagy and suppression of protein kinases by aescin, a triterpenoid saponin impedes lung cancer progression. Int J BiolMacromol. 2023 Aug 12;252:126328. (JIF=7.2). 
    5. Hussain Y, Meena A, Sinha RA. Gossypol synergises antiproliferative effect of sorafenib in metastatic lung cancer cells following Chou-Talalay algorithm. Toxicol In Vitro. 2023 Aug 21;93:105666. (JIF=3.3). 
    6. Hussain Y, Chaudhary J, Meena A, Sinha RA, Lukman S. Escin enhanced the efficacy of sorafenib by autophagy-mediated apoptosis in lung cancer cells. Phytotherapy Research 2023; (Accepted). (JIF=6.2). 
    7. Tewari A, Rajak S, Raza S, Gupta P, Chakravarti B, Shrivastava J, Chaturvedi CP, Sinha RA*. Targeting Extracellular RNA Mitigates Hepatic Lipotoxicity and Liver Injury in NASH. Cells 2023; *Corresponding author (JIF=7.6). 
    8. Sinha RA*. Autophagy: A cellular guardian against hepatic lipotoxicity. Genes 2023; (Accepted), *Corresponding author (JIF=4.1). 
    9. Chakravarti B, Siddiqui JA, Sinha RA*, Raza S. Targeting autophagy and lipid metabolism in cancer stem cells. Biochemical Pharmacology 2023; (In Press), *Corresponding author (JIF=6.1). 
    10. Rajak S, Tewari A, Raza S, Gupta P, Chakravarti B, Tripathi M, Singh BK, Yen PM, Goel A, Ghosh S, Sinha RA*. Pharmacological inhibition of CFTR attenuates nonalcoholic steatohepatitis (NASH) progression in mice. Biochemica et Biophysica Acta (BBA)-Molecular Basis of Disease 2023; (Accepted), *Corresponding author (JIF=6.6). 
    11. Benjamin M, Malakar P, Sinha RA, Nasser MW, Batra SK, Siddiqui JA, Chakravarti B. Molecular signaling network and therapeutic developments in breast cancer brain metastasis, Adv Cancer Biol Metastasis, 2023; 100079. 
    12. Tripathi M, Singh BK, Zhou J, Tikno K, Widjaja A, Sandireddy R, Arul K, Abdul Ghani SAB, Bee GGB, Wong KA, Pei HJ, Shekeran SG, Sinha RA, Singh MK, Cook SA, Suzuki A, Lim TR, Cheah CC, Wang J, Xiao RP, Zhang X, Chow PKH, Yen PM. Vitamin B(12) and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation. J Hepatol 2022; 77:1246-1255 (JIF=30). 
    13. Tripathi M, Singh BK, Liehn EA, Lim SY, Tikno K, Castano-Mayan D, Rattanasopa C, Nilcham P, Abdul Ghani SAB, Wu Z, Azhar SH, Zhou J, Hernandez-Resendiz S, Crespo-
    1. Sinha RA, Farah BL, Moe KT, De Silva DA, Angeli V, Singh MK, Singaraja RR, Hausenloy DJ, Yen PM. Caffeine prevents restenosis and inhibits vascular smooth muscle cell proliferation through the induction of autophagy. Autophagy 2022:1-11 (JIF=13.3). 
    2. Raza S, Rajak S, Tewari A, Gupta P, Chattopadhyay N, Sinha RA, Chakravarti B. Multifaceted role of chemokines in solid tumors: From biology to therapy. Semin Cancer Biol 2022; (JIF=17.1). 
    3. Raza S, Rajak S, Srivastava J, Tewari A, Gupta P, Chakravarti B, Ghosh S, Chaturvedi CP, Sinha RA*. ULK1 inhibition attenuates telomerase activity in hepatic cells. BiochimBiophys Acta Mol Cell Res 2022; 1869:119355, *Corresponding author (JIF=5.0). 
    4. Hussain Y, Singh J, Raza W, Meena A, Rajak S, Sinha RA, Luqman S. Purpurin ameliorates alcohol-induced hepatotoxicity by reducing ROS generation and promoting Nrf2 expression. Life Sci. 2022 Nov 15;309:120964. (JIF =6.7). 
    5. Rajak S, Raza S, Sinha RA*. ULK1 Signaling in the Liver: Autophagy Dependent and Independent Actions. Front Cell Dev Biol 2022; 10:836021, *Corresponding author (JIF=6.0). 
    6. Rajak S, Gupta P, Anjum B, Raza S, Tewari A, Ghosh S, Tripathi M, Singh BK, Sinha RA*. Role of AKR1B10 and AKR1B8 in the pathogenesis of non-alcoholic steatohepatitis (NASH) in mouse. BiochimBiophys Acta Mol Basis Dis 2022; 1868:166319, *Corresponding author (JIF=6.6). 
    7. Chakravarti B, Rajput S, Raza S, Rajak S, Tewari A, Gupta P, Upadhyay A, Chattopadhyay N, Sinha RA*. Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness. BiochimBiophys Acta Mol Basis Dis 2022; 1868:166455, *Corresponding author (JIF=6.6). 
    8. Zhou J, Singh BK, Ho JP, Lim A, Bruinstroop E, Ohba K, Sinha RA, Yen PM. MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism. Autophagy 2021; 17:4043-4061, (JIF=13.3). 
    9. Zhou J, Tripathi M, Sinha RA, Singh BK, Yen PM. Gut microbiota and their metabolites in the progression of non-alcoholic fatty liver disease. Hepatoma Res 2021; 7:11. 
    10. Zhou J, Sinha RA, Yen PM. The roles of autophagy and thyroid hormone in the pathogenesis and treatment of NAFLD. Hepatoma Res 2021; 7:72. 
    11. Yadav S, Porwal K, Sinha RA, Chattopadhyay N, Gupta SK. Moderate/subclinical calcium deficiency attenuates trabecular mass, microarchitecture and bone growth in growing rats. BiochemBiophys Rep 2021; 26:101033. 
    12. Raza S, Tewari A, Rajak S, Sinha RA*. Vitamins and non-alcoholic fatty liver disease: A Molecular Insight. Liver Res 2021; 5:62-71. *Corresponding author. 
    13. Zhou J, Gauthier K, Ho JP, Lim A, Zhu XG, Han CR, Sinha RA, Cheng SY, Yen PM. Thyroid Hormone Receptor alpha Regulates Autophagy, Mitochondrial Biogenesis, and Fatty Acid Use in Skeletal Muscle. Endocrinology 2021; 162, (JIF=5.0). 
    14. Raza S, Rajak S, Upadhyay A, Tewari A, Sinha RA*. Current treatment paradigms and emerging therapies for NAFLD/NASH. Front Biosci (Landmark Ed) 2021; 26:206-237, *Corresponding author, (JIF=3.1). 
    1. Rajak S, Yen PM, Sinha RA*. MTORC1-dependent crinophagy regulates glucagon content in pancreatic alpha-cells. Autophagy 2021; 17:3269-3270, *Corresponding author (JIF=13.3). 
    2. Rajak S, Xie S, Tewari A, Raza S, Wu Y, Bay BH, Yen PM, Sinha RA*. MTORC1 inhibition drives crinophagic degradation of glucagon. Mol Metab 2021; 53:101286, *Corresponding author, (JIF=8.5). 
    3. Rajak S, Raza S, Tewari A, Sinha RA*. Environmental Toxicants and NAFLD: A Neglected yet Significant Relationship. Dig Dis Sci 2021; *Corresponding author (JIF=3.5). 
    4. Pal S, Singh M, Porwal K, Rajak S, Das N, Rajput S, Trivedi AK, Maurya R, Sinha RA, Siddiqi MI, Sanyal S, Chattopadhyay N. Adiponectin receptors by increasing mitochondrial biogenesis and respiration promote osteoblast differentiation: Discovery of isovitexin as a new class of small molecule adiponectin receptor modulator with potential osteoanabolic function. Eur J Pharmacol 2021; 913:174634, (JIF=5.19). 
    5. KlionskyDJ,…..Sinha RA. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1). Autophagy 2021; 17:1-382, (JIF=13.3). 
    6. Yadav S, Pal S, Singh P, Porwal K, Sinha RA, Kumari N, Chattopadhyay N, Gupta SK. Calcium repletion to rats with calcipenic rickets fails to recover bone quality: A calcipenic "memory". Bone 2020; 141:115562, (JIF=4.6). 
    7. Upadhyay A, Sinha RA*, Kumar A, Godbole MM. Time-restricted feeding ameliorates maternal high-fat diet-induced fetal lung injury. Exp Mol Pathol 2020; 114:104413, *Corresponding author, (JIF=4.4). 
    8. Sinha RA*, Rajak S, Singh BK, Yen PM. Hepatic Lipid Catabolism via PPARalpha-Lysosomal Crosstalk. Int J Mol Sci 2020; 21 *Corresponding author, (JIF=6.2). 
    9. Sinha RA, Bruinstroop E, Singh BK, Yen PM. Thyroid Hormones and Thyromimetics: A New Approach to Nonalcoholic Steatohepatitis? Hepatology 2020; 72:770-771, (JIF=17.2). 
    10. Rajak S, Raza S, Tewari A, Yadav S, Ghosh S, Yen PM, Sinha RA*. Autophagic protein ULK1 regulates FOXM1 signalling in human hepatoma cells. BiochemBiophys Res Commun 2020; 532:570-575, *Corresponding author, (JIF=3.3). 
    11. Rajak S, Iannucci LF, Zhou J, Anjum B, George N, Singh BK, Ghosh S, Yen PM, Sinha RA*. Loss of ULK1 Attenuates Cholesterogenic Gene Expression in Mammalian Hepatic Cells. Front Cell Dev Biol 2020; 8:523550, *Corresponding author (JIF=6.0). 
    12. Pandey R, Shukla P, Anjum B, Gupta HP, Pal S, Arjaria N, Gupta K, Chattopadhyay N, Sinha RA*, Bandyopadhyay S. Estrogen deficiency induces memory loss via altered hippocampal HB-EGF and autophagy. J Endocrinol 2020; 244:53-70, *Corresponding author, (JIF=4.66). 
    13. Pal S, Porwal K, Rajak S, Sinha RA, Chattopadhyay N. Selective dietary polyphenols induce differentiation of human osteoblasts by adiponectin receptor 1-mediated reprogramming of mitochondrial energy metabolism. Biomed Pharmacother 2020; 127:110207, (JIF=7.4). 
    14. Kumar A, Kalita J, Sinha RA, Singh G, B A, Shukla M, Tiwari S, Dhole TN, Misra UK. Impaired Autophagy Flux is Associated with Proinflammatory Microglia Activation Following Japanese Encephalitis Virus Infection. Neurochem Res 2020; 45:2184-2195, (JIF=4.4). 
    15. Godbole NM, Sinha RA*, Tiwari S, Pawar SD, Dhole TN. Analysis of influenza virus-induced perturbation in autophagic flux and its modulation during Vitamin D3 mediated anti-apoptotic signaling. Virus Res 2020; 282:197936, *Corresponding author, (JIF=6.2). 
    16. Raza S, Rajak S, Anjum B, Sinha RA*. Molecular links between non-alcoholic fatty liver disease and hepatocellular carcinoma. Hepatoma Res 2019; 5:42. *Corresponding author. 
    17. Zhou J, Ng B, Ko NSJ, Fiedler LR, Khin E, Lim A, Sahib NE, Wu Y, Chothani SP, Schafer S, Bay BH, Sinha RA, Cook SA, Yen PM. Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo. Hum Mol Genet 2019; 28:1971-1981, (JIF=5.1). 
    18. Yau WW, Singh BK, Lesmana R, Zhou J, Sinha RA, Wong KA, Wu Y, Bay BH, Sugii S, Sun L, Yen PM. Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy. Autophagy 2019; 15:131-150, (JIF=13.3). 
    19. Widjaja AA, Singh BK, Adami E, Viswanathan S, Dong J, D'Agostino GA, Ng B, Lim WW, Tan J, Paleja BS, Tripathi M, Lim SY, Shekeran SG, Chothani SP, Rabes A, Sombetzki M, Bruinstroop E, Min LP, Sinha RA, Albani S, Yen PM, Schafer S, Cook SA. Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis. Gastroenterology 2019; 157:777-792 e714, (JIF=33.8). 
    20. Upadhyay A, Anjum B, Godbole NM, Rajak S, Shukla P, Tiwari S, Sinha RA*, Godbole MM. Time-restricted feeding reduces high-fat diet associated placental inflammation and limits adverse effects on fetal organ development. BiochemBiophys Res Commun 2019; 514:415-421, *Corresponding author, (JIF=3.3). 
    21. Tan HWS, Anjum B, Shen HM, Ghosh S, Yen PM, Sinha RA*. Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels. Autophagy 2019; 15:1455-1459, *Corresponding author, (JIF=13.3). 
    22. Sinha RA, Bruinstroop E, Singh BK, Yen PM. Nonalcoholic Fatty Liver Disease and Hypercholesterolemia: Roles of Thyroid Hormones, Metabolites, and Agonists. Thyroid 2019; 29:1173-1191, (JIF=6.5). 
    23. Pal S, Maurya SK, Chattopadhyay S, Pal China S, Porwal K, Kulkarni C, Sanyal S, Sinha RA, Chattopadhyay N. The osteogenic effect of liraglutide involves enhanced mitochondrial biogenesis in osteoblasts. BiochemPharmacol 2019; 164:34-44, (JIF=6.1). 
    24. Minocha E, Sinha RA, Jain M, Chaturvedi CP, Nityanand S. Amniotic fluid stem cells ameliorate cisplatin-induced acute renal failure through induction of autophagy and inhibition of apoptosis. Stem Cell Res Ther 2019; 10:370, (JIF=8.0). 
    25. Sinha RA*, Singh BK, Yen PM. Direct effects of thyroid hormones on hepatic lipid metabolism. Nat Rev Endocrinol 2018; 14:259-269, *Corresponding author, (JIF=47.5). 
    26. Singh BK, Sinha RA, Yen PM. Novel Transcriptional Mechanisms for Regulating Metabolism by Thyroid Hormone. Int J Mol Sci 2018; 19, (JIF=6.2). 
    27. Sinha R, Yen PM. Cellular Action of Thyroid Hormone. Endotext, South Dartmouth (MA), 2018. 
    28. Singh BK, Sinha RA, Tripathi M, Mendoza A, Ohba K, Sy JAC, Xie SY, Zhou J, Ho JP, Chang CY, Wu Y, Giguere V, Bay BH, Vanacker JM, Ghosh S, Gauthier K, Hollenberg AN, McDonnell DP, Yen PM. Thyroid hormone receptor and ERRalphacoordinately regulate mitochondrial fission, mitophagy, biogenesis, and function. Sci Signal 2018; 11, (JIF=9.5). 
    29. J. Zhou, R.A. Sinha#, R. Lesmana, W.W.Y. Yau, P.M. Yen, Pharmacological Inhibition of Lysosomal Activity as a Method For Monitoring Thyroid Hormone-induced Autophagic Flux in Mammalian Cells In Vitro, Methods Mol Biol, 1801 (2018) 111-122. #Co-First author. 
    30. Rastogi L, Godbole MM, Sinha RA, Pradhan S. Reverse triiodothyronine (rT3) attenuates ischemia-reperfusion injury. BiochemBiophys Res Commun 2018; 506:597-603, (JIF=3.3). 
    31. Kumar P, Godbole NM, Chaturvedi CP, Singh RS, George N, Upadhyay A, Anjum B, Godbole MM, Sinha RA*. Mechanisms involved in epigenetic down-regulation of Gfap under maternal hypothyroidism. BiochemBiophys Res Commun 2018; 502:375-381, *Corresponding author (JIF=3.3). 
    32. Bruinstroop E, Dalan R, Cao Y, Bee YM, Chandran K, Cho LW, Soh SB, Teo EK, Toh SA, Leow MKS, Sinha RA, Sadananthan SA, Michael N, Stapleton HM, Leung C, Angus PW, Patel SK, Burrell LM, Lim SC, Sum CF, Velan SS, Yen PM. Low-Dose Levothyroxine Reduces Intrahepatic Lipid Content in Patients With Type 2 Diabetes Mellitus and NAFLD. J Clin Endocrinol Metab 2018; 103:2698-2706, (JIF=6.1) 
    33. Zhou J, Chong SY, Lim A, Singh BK, Sinha RA, Salmon AB, Yen PM. Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging. Aging (Albany NY) 2017; 9:583-599, (JIF=5.9) 
    34. Sinha RA*, Singh BK, Zhou J, Xie S, Farah BL, Lesmana R, Ohba K, Tripathi M, Ghosh S, Hollenberg AN, Yen PM. Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells. Autophagy 2017; 13:169-186, *Corresponding author (JIF=13.3) 
    35. Sinha RA*, Singh BK, Yen PM. Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis. Endocr Rev 2017; 38:69-102, *Corresponding author, (JIF=25.2) 
    36. Singh BK, Sinha RA, Ohba K, Yen PM. Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy. Mol Cell Endocrinol 2017; 458:160-168, (JIF=4.3) 
    37. Ohba K, Sinha RA, Singh BK, Iannucci LF, Zhou J, Kovalik JP, Liao XH, Refetoff S, Sng JCG, Leow MK, Yen PM. Changes in Hepatic TRbeta Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model. Thyroid 2017; 27:852-860, (JIF=6.5) 
    38. Iannucci LF, Cioffi F, Senese R, Goglia F, Lanni A, Yen PM, Sinha RA*. Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet. Sci Rep 2017; 7:2023, *Corresponding author, (JIF=4.9) 
    39. Farah BL, Sinha RA, Wu Y, Singh BK, Lim A, Hirayama M, Landau DJ, Bay BH, Koeberl DD, Yen PM. Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa). Sci Rep 2017; 7:44408, (JIF=4.9). 
    40. Farah BL, Landau DJ, Wu Y, Sinha RA, Loh A, Bay BH, Koeberl DD, Yen PM. Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia. Mol Genet Metab 2017; 122:95-98, (JIF=4.2). 
    41. Tripathi M, Zhang CW, Singh BK, Sinha RA, Moe KT, DeSilva DA, Yen PM. Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. Cell Death Dis 2016; 7:e2513. (JIF=9.6) 
    42. Sinha RA, Yen PM. Mechanisms for Thyroid Hormone Action in the CNS, in: N. Koibuchi, P.M. Yen (Eds.) Thyroid Hormone Disruption and Neurodevelopment, Springer New York, New York, NY, 2016, pp. 3-21. 
    43. Sinha RA, Yen PM. Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD. Cell Biosci 2016; 6:46, (JIF=9.5) 
    44. Singh BK, Sinha RA, Zhou J, Tripathi M, Ohba K, Wang ME, Astapova I, Ghosh S, Hollenberg AN, Gauthier K, Yen PM. Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. J Biol Chem 2016; 291:198-214, (JIF=5.4) 
    45. Ohba K, Leow MK, Singh BK, Sinha RA, Lesmana R, Liao XH, Ghosh S, Refetoff S, Sng JC, Yen PM. Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice. Endocrinology 2016; 157:1660-1672, (JIF=5.0) 
    46. Lim A, Zhou J, Sinha RA, Singh BK, Ghosh S, Lim KH, Chow PK, Woon ECY, Yen PM. Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity. BiochemBiophys Res Commun 2016; 479:476-481, (JIF=3.3) 
    47. Lesmana R, Sinha RA, Singh BK, Zhou J, Ohba K, Wu Y, Yau WW, Bay BH, Yen PM. Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle. Endocrinology 2016; 157:23-38, (JIF=5.0) 
    48. Iannucci LF, Sun J, Singh BK, Zhou J, Kaddai VA, Lanni A, Yen PM, Sinha RA*. Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells. BiochemBiophys Res Commun 2016; 480:461-467, *Corresponding author, (JIF=3.3). 
    49. Farah BL, Landau DJ, Sinha RA, Brooks ED, Wu Y, Fung SYS, Tanaka T, Hirayama M, Bay BH, Koeberl DD, Yen PM. Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency. J Hepatol 2016; 64:370-379, (JIF=30) 
    50. Zhou J, Yong WP, Yap CS, Vijayaraghavan A, Sinha RA, Singh BK, Xiu S, Manesh S, Ngo A, Lim A, Ang C, Xie C, Wong FY, Lin SJ, Wan WK, Tan IB, Flotow H, Tan P, Lim KH, Yen PM, Goh LK. An integrative approach identified genes associated with drug response in gastric cancer. Carcinogenesis 2015; 36:441-451, (JIF=4.7). 
    51. Sinha RA*, Singh BK, Zhou J, Wu Y, Farah BL, Ohba K, Lesmana R, Gooding J, Bay BH, Yen PM. Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling. Autophagy 2015; 11:1341-1357, *Corresponding author, (JIF=13.3). 
    52. Kumar P, Mohan V, Sinha RA*, Chagtoo M, Godbole MM. Histone deacetylase inhibition reduces hypothyroidism-induced neurodevelopmental defects in rats. J Endocrinol 2015; 227:83-92, *Corresponding author, (JIF=4.6). 
    53. Zhou J, Farah BL, Sinha RA, Wu Y, Singh BK, Bay BH, Yang CS, Yen PM. Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance. PLoS One 2014; 9:e87161, (JIF=3.7) 
    54. Sinha RA, Singh BK, Yen PM. Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism. Trends Endocrinol Metab 2014; 25:538-545, (JIF=10.5). 
    55. Sinha RA, Farah BL, Singh BK, Siddique MM, Li Y, Wu Y, Ilkayeva OR, Gooding J, Ching J, Zhou J, Martinez L, Xie S, Bay BH, Summers SA, Newgard CB, Yen PM. Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. Hepatology 2014; 59:1366-1380, (JIF=17.5). 
    56. Farah BL, Sinha RA, Wu Y, Singh BK, Zhou J, Bay BH, Yen PM. beta-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liver. PLoS One 2014; 9:e98155, (JIF=3.7). 
    57. Aw DK, Sinha RA#, Xie SY, Yen PM. Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells. BiochemBiophys Res Commun 2014; 447:569-573, #Co-First author (JIF=3.3). 
    58. Aw DK, Sinha RA#, Tan HC, Loh LM, Salvatore D, Yen PM. Studies of molecular mechanisms associated with increased deiodinase 3 expression in a case of consumptive hypothyroidism. J Clin Endocrinol Metab 2014; 99:3965-3971, #Co-First Author, (JIF=6.1). 
    59. Yap CS, Sinha RA, Ota S, Katsuki M, Yen PM. Thyroid hormone negatively regulates CDX2 and SOAT2 mRNA expression via induction of miRNA-181d in hepatic cells. BiochemBiophys Res Commun 2013; 440:635-639, (JIF=3.3). 
    60. Xie S, Sinha RA#, Singh BK, Li GD, Han W, Yen PM. Resveratrol induces insulin gene expression in mouse pancreatic alpha-cells. Cell Biosci 2013; 3:47, #Co-First Author (JIF=9.5) 
    61. Singh BK, Sinha RA, Zhou J, Xie SY, You SH, Gauthier K, Yen PM. FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes. J Biol Chem 2013; 288:30365-30372, (JIF=5.4). 
    62. Pal A, Mohan V, Modi DR, Sinha RA, Rastogi L, Kumar P, Godbole MM. Iodine plus n-3 fatty acid supplementation augments rescue of postnatal neuronal abnormalities in iodine-deficient rat cerebellum. Br J Nutr 2013; 110:659-670, (JIF=4.1). 
    63. Zhou J, Chen GB, Tang YC, Sinha RA, Wu Y, Yap CS, Wang G, Hu J, Xia X, Tan P, Goh LK, Yen PM. Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library. BMC Med Genomics 2012; 5:34, (JIF=3.6). 
    64. Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky ML, Cheng SY, Stevens RD, Summers SA, Newgard CB, Lazar MA, Yen PM. Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. J Clin Invest 2012; 122:2428-2438, (JIF=19.45). 
    65. Mohan V, Sinha RA, Pathak A, Rastogi L, Kumar P, Pal A, Godbole MM. Maternal thyroid hormone deficiency affects the fetalneocorticogenesis by reducing the proliferating pool, rate of neurogenesis and indirect neurogenesis. Exp Neurol 2012; 237:477-488, (JIF=5.6). 
    66. Pathak A, Sinha RA, Mohan V, Mitra K, Godbole MM. Maternal thyroid hormone before the onset of fetal thyroid function regulates reelin and downstream signaling cascade affecting neocortical neuronal migration. Cereb Cortex 2011; 21:11-21, (JIF=4.8). 
    67. Babu S, Sinha RA, Mohan V, Rao G, Pal A, Pathak A, Singh M, Godbole MM. Effect of hypothyroxinemia on thyroid hormone responsiveness and action during rat postnatal neocortical development. Exp Neurol 2011; 228:91-98. (JIF=5.6). 
    68. Sinha RA, Pathak A, Mohan V, Babu S, Pal A, Khare D, Godbole MM. Evidence of a bigenomic regulation of mitochondrial gene expression by thyroid hormone during rat brain development. BiochemBiophys Res Commun 2010; 397:548-552. (JIF=3.3). 
    69. Sinha RA, Pathak A, Kumar A, Tiwari M, Shrivastava A, Godbole MM. Enhanced neuronal loss under perinatal hypothyroidism involves impaired neurotrophic signaling and increased proteolysis of p75(NTR). Mol Cell Neurosci 2009; 40:354-364, (JIF=4.6). 
    70. Sinha RA, Khare P, Rai A, Maurya SK, Pathak A, Mohan V, Nagar GK, Mudiam MK, Godbole MM, Bandyopadhyay S. Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model. Int J Dev Neurosci 2009; 27:377-383, (JIF=2.5). 
    71. Tiwari M, Bajpai VK, Sahasrabuddhe AA, Kumar A, Sinha RA, Behari S, Godbole MM. Inhibition of N-(4-hydroxyphenyl)retinamide-induced autophagy at a lower dose enhances cell death in malignant glioma cells. Carcinogenesis 2008; 29:600-609, (JIF=4.7). 
    72. Sinha RA, Pathak A, Mohan V, Bandyopadhyay S, Rastogi L, Godbole MM. Maternal thyroid hormone: a strong repressor of neuronal nitric oxide synthase in rat embryonic neocortex. Endocrinology 2008; 149:4396-4401, (JIF=5.0). 
    73. Kumar A, Sinha RA, Tiwari M, Singh R, Koji T, Manhas N, Rastogi L, Pal L, Shrivastava A, Sahu RP, Godbole MM. Hyperthyroidism induces apoptosis in rat liver through activation of death receptor-mediated pathways. J Hepatol 2007; 46:888-898, (JIF=30). 
    74. Tiwari M, Kumar A, Sinha RA, Shrivastava A, Balapure AK, Sharma R, Bajpai VK, Mitra K, Babu S, Godbole MM. Mechanism of 4-HPR-induced apoptosis in glioma cells: evidences suggesting role of mitochondrial-mediated pathway and endoplasmic reticulum stress. Carcinogenesis 2006; 27:2047-2058, (JIF=4.7) 
    75. Shrivastava A, Tiwari M, Sinha RA, Kumar A, Balapure AK, Bajpai VK, Sharma R, Mitra K, Tandon A, Godbole MM. Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway. J Biol Chem 2006; 281:19762-19771, (JIF=5.4). 
    76. Kumar A, Sinha RA, Tiwari M, Pal L, Shrivastava A, Singh R, Kumar K, Kumar Gupta S, Godbole MM. Increased pro-nerve growth factor and p75 neurotrophin receptor levels in developing hypothyroid rat cerebral cortex are associated with enhanced apoptosis. Endocrinology 2006; 147:4893-4903, (JIF=5.4). 
    77. Zhou J, Yong WP, Yap CS, Vijayaraghavan A, Sinha RA, Singh BK, Xiu S, Manesh S, Ngo A, Lim A, Ang C, Xie C, Wong FY, Lin SJ, Wan WK, Tan IB, Flotow H, Tan P, Lim KH, Yen PM, Goh LK. An integrative approach identified genes associated with drug response in gastric cancer. Carcinogenesis 2015; 36:441-451, (JIF=4.7). 
    78. Sinha RA*, Singh BK, Zhou J, Wu Y, Farah BL, Ohba K, Lesmana R, Gooding J, Bay BH, Yen PM. Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling. Autophagy 2015; 11:1341-1357, *Corresponding author, (JIF=13.3). 
    79. Kumar P, Mohan V, Sinha RA*, Chagtoo M, Godbole MM. Histone deacetylase inhibition reduces hypothyroidism-induced neurodevelopmental defects in rats. J Endocrinol 2015; 227:83-92, *Corresponding author, (JIF=4.6). 
    80. Zhou J, Farah BL, Sinha RA, Wu Y, Singh BK, Bay BH, Yang CS, Yen PM. Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance. PLoS One 2014; 9:e87161, (JIF=3.7) 
    81. Sinha RA, Singh BK, Yen PM. Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism. Trends Endocrinol Metab 2014; 25:538-545, (JIF=10.5). 
    82. Sinha RA, Farah BL, Singh BK, Siddique MM, Li Y, Wu Y, Ilkayeva OR, Gooding J, Ching J, Zhou J, Martinez L, Xie S, Bay BH, Summers SA, Newgard CB, Yen PM. Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. Hepatology 2014; 59:1366-1380, (JIF=17.5). 
    83. Farah BL, Sinha RA, Wu Y, Singh BK, Zhou J, Bay BH, Yen PM. beta-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liver. PLoS One 2014; 9:e98155, (JIF=3.7). 
    84. Aw DK, Sinha RA#, Xie SY, Yen PM. Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells. BiochemBiophys Res Commun 2014; 447:569-573, #Co-First author (JIF=3.3). 
    85. Aw DK, Sinha RA#, Tan HC, Loh LM, Salvatore D, Yen PM. Studies of molecular mechanisms associated with increased deiodinase 3 expression in a case of consumptive hypothyroidism. J Clin Endocrinol Metab 2014; 99:3965-3971, #Co-First Author, (JIF=6.1). 
    86. Yap CS, Sinha RA, Ota S, Katsuki M, Yen PM. Thyroid hormone negatively regulates CDX2 and SOAT2 mRNA expression via induction of miRNA-181d in hepatic cells. BiochemBiophys Res Commun 2013; 440:635-639, (JIF=3.3). 
    87. Xie S, Sinha RA#, Singh BK, Li GD, Han W, Yen PM. Resveratrol induces insulin gene expression in mouse pancreatic alpha-cells. Cell Biosci 2013; 3:47, #Co-First Author (JIF=9.5) 
    88. Singh BK, Sinha RA, Zhou J, Xie SY, You SH, Gauthier K, Yen PM. FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes. J Biol Chem 2013; 288:30365-30372, (JIF=5.4). 
    89. Pal A, Mohan V, Modi DR, Sinha RA, Rastogi L, Kumar P, Godbole MM. Iodine plus n-3 fatty acid supplementation augments rescue of postnatal neuronal abnormalities in iodine-deficient rat cerebellum. Br J Nutr 2013; 110:659-670, (JIF=4.1). 
    90. Zhou J, Chen GB, Tang YC, Sinha RA, Wu Y, Yap CS, Wang G, Hu J, Xia X, Tan P, Goh LK, Yen PM. Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library. BMC Med Genomics 2012; 5:34, (JIF=3.6). 
    91. Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky ML, Cheng SY, Stevens RD, Summers SA, Newgard CB, Lazar MA, Yen PM. Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. J Clin Invest 2012; 122:2428-2438, (JIF=19.45). 
    92. Mohan V, Sinha RA, Pathak A, Rastogi L, Kumar P, Pal A, Godbole MM. Maternal thyroid hormone deficiency affects the fetalneocorticogenesis by reducing the proliferating pool, rate of neurogenesis and indirect neurogenesis. Exp Neurol 2012; 237:477-488, (JIF=5.6). 
    93. Pathak A, Sinha RA, Mohan V, Mitra K, Godbole MM. Maternal thyroid hormone before the onset of fetal thyroid function regulates reelin and downstream signaling cascade affecting neocortical neuronal migration. Cereb Cortex 2011; 21:11-21, (JIF=4.8). 
    94. Babu S, Sinha RA, Mohan V, Rao G, Pal A, Pathak A, Singh M, Godbole MM. Effect of hypothyroxinemia on thyroid hormone responsiveness and action during rat postnatal neocortical development. Exp Neurol 2011; 228:91-98. (JIF=5.6). 
    95. Sinha RA, Pathak A, Mohan V, Babu S, Pal A, Khare D, Godbole MM. Evidence of a bigenomic regulation of mitochondrial gene expression by thyroid hormone during rat brain development. BiochemBiophys Res Commun 2010; 397:548-552. (JIF=3.3). 
    96. Sinha RA, Pathak A, Kumar A, Tiwari M, Shrivastava A, Godbole MM. Enhanced neuronal loss under perinatal hypothyroidism involves impaired neurotrophic signaling and increased proteolysis of p75(NTR). Mol Cell Neurosci 2009; 40:354-364, (JIF=4.6). 
    97. Sinha RA, Khare P, Rai A, Maurya SK, Pathak A, Mohan V, Nagar GK, Mudiam MK, Godbole MM, Bandyopadhyay S. Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model. Int J Dev Neurosci 2009; 27:377-383, (JIF=2.5). 
    98. Tiwari M, Bajpai VK, Sahasrabuddhe AA, Kumar A, Sinha RA, Behari S, Godbole MM. Inhibition of N-(4-hydroxyphenyl)retinamide-induced autophagy at a lower dose enhances cell death in malignant glioma cells. Carcinogenesis 2008; 29:600-609, (JIF=4.7). 
    99. Sinha RA, Pathak A, Mohan V, Bandyopadhyay S, Rastogi L, Godbole MM. Maternal thyroid hormone: a strong repressor of neuronal nitric oxide synthase in rat embryonic neocortex. Endocrinology 2008; 149:4396-4401, (JIF=5.0). 
    100. Kumar A, Sinha RA, Tiwari M, Singh R, Koji T, Manhas N, Rastogi L, Pal L, Shrivastava A, Sahu RP, Godbole MM. Hyperthyroidism induces apoptosis in rat liver through activation of death receptor-mediated pathways. J Hepatol 2007; 46:888-898, (JIF=30). 
    101. Tiwari M, Kumar A, Sinha RA, Shrivastava A, Balapure AK, Sharma R, Bajpai VK, Mitra K, Babu S, Godbole MM. Mechanism of 4-HPR-induced apoptosis in glioma cells: evidences suggesting role of mitochondrial-mediated pathway and endoplasmic reticulum stress. Carcinogenesis 2006; 27:2047-2058, (JIF=4.7) 
    102. Shrivastava A, Tiwari M, Sinha RA, Kumar A, Balapure AK, Bajpai VK, Sharma R, Mitra K, Tandon A, Godbole MM. Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway. J Biol Chem 2006; 281:19762-19771, (JIF=5.4). 
    103. Kumar A, Sinha RA, Tiwari M, Pal L, Shrivastava A, Singh R, Kumar K, Kumar Gupta S, Godbole MM. Increased pro-nerve growth factor and p75 neurotrophin receptor levels in developing hypothyroid rat cerebral cortex are associated with enhanced apoptosis. Endocrinology 2006; 147:4893-4903, (JIF=5.4). 

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