Research

Completed:

  1. To study the role of Ivabradine in controlling Heart Rate in Chronic Atrial Fibrillation associated with Rheumatic Heart Disease, 2022, Funding :Departmental (PI: Dr Aditya Kapoor), Status: Accepted for publication in Indian Heart Journal, Summary report:Ivabradine was used in 80 patients, rheumatic AF, HR > 100 bpm (age 47 ±11 yrs, AF duration 6.8 ±2.9 years, rate 131± 16 bpm) on maximally tolerated ββ or CCB’s. It resulted in significantly lower HR (81 ±10 vs 99 + 9) at 3 months and 6 months (79 ± 8 vs 94 ±8, p < 0.001) with better day-time and night-time Holter rate control, lower NT Pro BNP and  higher 6 minute walk distance with better LA Strain values (22.8±2.8% vs 20.6 ± 2.5%).  Our data suggest that Ivabradine can be an option for rate control in rheumatic AF.
  2. Does High dose Statin Pretreatment Affect Global and Regional Strain in Patients undergoing CABG and Valve Replacement, 2022. Funding : Departmental (PI: Dr Aditya Kapoor), Status: Communicated for publication Summary report:Pre-operative high dose rosuvastatin was “cardioprotective” with favorable effect on LV global strain and release kinetics of biomarkers. These cut-offs (described for the first time for rheumatic VR) can be used as prognostic predictors.
  3. Oral Flecainide for Acute Conversion and maintenance of sinus rhythm in post mitral valve replacement patients with Rheumatic Atrial Fibrillation, 2022., FundingDepartmental (PI: Dr Aditya Kapoor), Status: Communicated for publication, Summary report:Oral flecainide was effective in achieving and maintaining SR in post MVR patients with rheumatic AF. Maintenance of SR was achieved in 79 % of initial converters and 64% of overall population, with better LA strain values.  Flecainide was well tolerated.  As patients of rheumatic AF are often young and unlikely to have underlying coronary artery disease or severe LV dysfunction, flecainide is a potentially attractive modality for achieving and maintaining SR in these patients. 
  4. Comparison of Radial Artery outcomes with chitosan based haemostatic dressing AXIOSTAT® vs Mechanical Compression (TR BAND) for patients undergoing transradial coronary intervention - an open label randomised controlled trial, 202, Funding :Departmental (PI: Dr Naveeen Garg), Summary of results: This study randomized 258 patients undergoing transradial coronary into 2 groups; radial hemostasis using radial TR band mechanical compression device and radial hemostasis using Axiostat a chitosan-based pad. The chitosan-based pad showed significantly greater efficiency in achieving hemostasis and fewer vascular complications compared to mechanical compression device.
  5. Delineating the role of the human leukocyte antigen locus in susceptibility to rheumatic heart disease in South Asia and Oceania, 2022, Funding :BMA Foundation, UK (PI: Dr Balraj Mittal, Co-PI:Naveen Garg), Summary report:.It was a genome-wide association study (GWAS) of Rheumatic Heart Disease susceptibility in 1,163 South Asians (672 cases; 491 controls) recruited in India and Fiji. We identify a novel susceptibility signal in the class III region of the human leukocyte antigen (HLA) complex in the South Asians. These findings suggest the class III region is a key determinant of RHD susceptibility offering important new insight into pathogenesis.
  6. Assessment of LA functions using ratio of mitral Doppler inflow velocity and tissue Doppler mitral annular velocity along with LA stain as a predictor of severity of coronary artery disease in stable angina patients, 2022., Funding :Departmental (PI: Dr Satyendra Tewari), Status: Completed , Summary report: Our study shows a significant association between LA function parameters (PALS, LAsSR, LAeSR, E/e`), with the presence of significant CAD in patients with stable angina symptoms.
  7. Assessment of Lipoprotein (a), Apolipoprotein B, Apolipoprotein A-1, ApoB/Apo A1 ratio and other attributable risk factors in predicting the severity of premature coronary artery disease (CAD), 2022.,Funding :Departmental (PI: Dr Satyendra Tewari), Status: Completed , Summary report: We observed a gradual increase in Lp (a) and Apo-B/A1 levels with the increasing number of stenotic vessels and an independent association between Lp (a) and the severity of CAD after adjusting for other possible confounding factors. There is a need to selectively reduce plasma Lp (a) and Apo B levels to reduce CAD severity in both primary and secondary prevention settings in order to define more accurately who to treat and to what targets.
  8. Clinico-echocardiographic study of Cardiac Sarcoidosis with special reference to Speckle tracking Imaging, 2022.Funding :Departmental (PI: Dr Sudeep Kumar), Status: Completed Summary report:.On speckle tracking echocardiography abnormal strain pattern seen in 48.39 % in  LV- GLS , 83.8 % in LV-GCS, 58 % in LV- GRS and 67.7 % in RV- GLS. Strain patterns were found to be abnormal even in patients with normal EF with mean LV- GCS -12.9± 8, RV-GLS -18± 5.3. In patients without cardiac involvement evidenced by FDG-PET/CMR  strain patterns were found to be abnormal with a mean LV-GLS -13± 4, LV-GCS -9.3 ± 6.5, RV-GLS - 15± 7.8.

 

  1. Research in progress

Funding agency, Name of project, Investigators

  1. Hamilton Health Sciences, CANADA, PHRI           INVICTUS- Investigation of Rheumatic AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies        Dr Sudeep Kumar, Dr Aditya Kapoor
  2. Hamilton Health Sciences, CANADA, PHRI           Investigation of Rheumatic AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin - Registry   Dr Sudeep Kumar, Dr Aditya Kapoor
  3. Investigator initiated   COVID19InfectedST-ElevationMyocardialInfarctioninINDIA(COSTAINDIA)   Dr Sudeep Kumar, Dr Aditya Kapoor
  4. ICMR: Understanding pathogenesis of Takayasu arteritis – transcriptomics applied to peripheral blood mononuclear cells (PBMC) and involved vessels, and the role of various T-cell subsets      Dr Sudeep Kumar
  5. IRA: Evaluation of clinical and serologic parameters predisposing to subclinical atherosclerosis in scleroderma     Dr Sudeep Kumar
  6. The George Institute for Global Health,  AUSTRALIA       Preventing Adverse Cardiac Events (PACE) in Chronic Obstructive pulmonary disease         Dr Sudeep Kumar
  7. ICMR:Analogue of prothrombin time: identification and assay development of novel non-invasive and surrogate indicator of blood coagulopathy. (with CBMR)    Dr Sudeep KumarDr Aditya Kapoor
  8. ICMR: Appraisal of cardiac energetic metabolism using blood sample of cardiac hypertrophy subjects (with CBMR)           Dr Sudeep Kumar
  9. ICMR: Breast artery calcification – A predictor of coronary artery disease in Women? A hospital-based study in Indian women (BAC-CAD STUDY)Dr Roopali KhannaDr Namita Mohindra
  10. ICMR: Identification of genetic variants and their functional evaluation in the pathogenesis of Inherited Cardiomyopathies       PI: Dr Anshika Srivastava, Co-PI: Dr Naveen Garg
  11. DBT: Harnessing genome sequencing and engineering (CRISPR/Cas9) technologies for identification of shared genetic and molecular aetiology in paediatric and adult cardiomyopathies          PI: Dr Anshika Srivastava, Co-PI: Dr Naveen Garg
  12. Department of Health Research, Govt. of India.       Understanding the role of gut microbiome and associatedimmuno-modulation in patho-physiology of atherosclerosis, Dr Naveen Garg

 

Other ongoing research

  1. RADPAD protection in Cath lab: Utility for primary and secondary operator
  2. Use of strain imaging to detect subtle myocardial involvement in post COVID-19 patients: An Indian perspective
  1. Funding :Departmental (PI: Dr Aditya Kapoor)
  1. A COMPARATIVE STUDY OF GLS, E/e’, and LEFT ATRIAL APPENDAGE WALL VELOCITY IN CORRELATION TO EJECTION FRACTION AND NT-probnp IN ISCHEMIC AND NON ISCHEMIC HEART FAILURE
  1. Funding :Departmental (PI: Dr Satyendra Tewari)
  1. Comparison of Radial Artery outcomes with chitosan based haemostatic dressing AXIOSTAT® vs Mechanical Compression (TR BAND) for patients undergoing transradial coronary intervention - an open label randomised controlled trial
  1. Comparison of ECG recording by standard 12 lead ECG and Kardia Mobile Device.
    1. Funding :Departmental (PI: Dr Naveeen Garg)
  2. Strain imaging to assess immediate and short term effects of successful percutaneous balloon mitral valvotomy on left atrial and Right Ventricular Mechanics
    1. Funding :Departmental (PI: Dr Sudeep Kumar)
  1. Breast Artery Calcification – A Predictor Of Coronary Artery Disease In Women? A Hospital-Based Study In Indian Women BAC-CAD Study
  1. Funding :Departmental (PI: Dr Roopali Khanna)
  1. Role of right atrial speckle tracking and strain imaging in pre-operative TOF patients., Funding :Departmental (PI: Dr Ankit Sahu)